Induction of penile erection by intracavernosal and transurethral administration of novel nitric oxide donors in the cat

Hunter C. Champion, Trinity J. Bivalacqua, Run Wang, Philip J. Kadowitz, Larry K. Keefer, Joseph E. Saavedra, Joseph A. Hrabie, Paul C. Doherty, Wayne J.G. Hellstrom

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: The effects of novel nitric oxide (NO) donors administered intracavernosalty and transurethrally on erectile function in the anesthetized cat were evaluated. Materials and Methods: In pentobarbital- anesthetized cats, increases in intracavernosal pressure, penile length, and duration of erectile response were determined after intracavernosal and transurethral injections of novel NO donors (MAHMA/NO, PAPA/NO, DEA/NO, PIPERAZI/NO and PROLI/NO). All parameters were measured after administration of NO donors intracavernosally via a 30-gauge needle and urethrally via a Jelco i.v. catheter in a volume of 200 μl. Systemic arterial pressure was also assessed in these experiments. All NO donors were compared with a triple-drug control combination comprised of papaverine (1.65 mg.), prostaglandin E1 (0.5 μg.), and phentolamine (25 μg.). Results: MAHMA/NO, PAPA/NO, DEA/NO, PIPERAZI/NO and PROLI/NO induced dose dependent increases in intracavernosal pressure and penile length (p <0.05) when administered intracavernosally. The increases in cavernosal pressure and penile length were comparable to those observed with the triple-drug control combination. The maximum increase in cavernosal pressure in response to PROLI/NO and PAPA/NO was associated with no significant change in systemic arterial pressure. Transurethral administration of PROLI/NO and PIPERAZI/NO induced dose-dependent increases in cavernosal pressure and penile length (p <0.05). The response was similar to that of the triple-drug control combination, except that transurethral PROLI/NO and PIPERAZI/NO had no significant effect on systemic blood pressure. Conclusions: NO donors caused dose-dependent increases in cavernosal pressure when administered intracavernosally and transurethrally. These data suggest further exploration of the use of NO donors for the treatment of erectile dysfunction.

Original languageEnglish (US)
Pages (from-to)2013-2019
Number of pages7
JournalJournal of Urology
Volume161
Issue number6
DOIs
StatePublished - Jun 1999
Externally publishedYes

Keywords

  • Diazeniumdiolates
  • Intracavernosal
  • Novel nitric oxide donors
  • Penile erection
  • Transurethral

ASJC Scopus subject areas

  • Urology

Fingerprint Dive into the research topics of 'Induction of penile erection by intracavernosal and transurethral administration of novel nitric oxide donors in the cat'. Together they form a unique fingerprint.

Cite this