Abstract
Purpose: The effects of novel nitric oxide (NO) donors administered intracavernosalty and transurethrally on erectile function in the anesthetized cat were evaluated. Materials and Methods: In pentobarbital- anesthetized cats, increases in intracavernosal pressure, penile length, and duration of erectile response were determined after intracavernosal and transurethral injections of novel NO donors (MAHMA/NO, PAPA/NO, DEA/NO, PIPERAZI/NO and PROLI/NO). All parameters were measured after administration of NO donors intracavernosally via a 30-gauge needle and urethrally via a Jelco i.v. catheter in a volume of 200 μl. Systemic arterial pressure was also assessed in these experiments. All NO donors were compared with a triple-drug control combination comprised of papaverine (1.65 mg.), prostaglandin E1 (0.5 μg.), and phentolamine (25 μg.). Results: MAHMA/NO, PAPA/NO, DEA/NO, PIPERAZI/NO and PROLI/NO induced dose dependent increases in intracavernosal pressure and penile length (p <0.05) when administered intracavernosally. The increases in cavernosal pressure and penile length were comparable to those observed with the triple-drug control combination. The maximum increase in cavernosal pressure in response to PROLI/NO and PAPA/NO was associated with no significant change in systemic arterial pressure. Transurethral administration of PROLI/NO and PIPERAZI/NO induced dose-dependent increases in cavernosal pressure and penile length (p <0.05). The response was similar to that of the triple-drug control combination, except that transurethral PROLI/NO and PIPERAZI/NO had no significant effect on systemic blood pressure. Conclusions: NO donors caused dose-dependent increases in cavernosal pressure when administered intracavernosally and transurethrally. These data suggest further exploration of the use of NO donors for the treatment of erectile dysfunction.
Original language | English (US) |
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Pages (from-to) | 2013-2019 |
Number of pages | 7 |
Journal | Journal of Urology |
Volume | 161 |
Issue number | 6 |
DOIs | |
State | Published - Jun 1999 |
Externally published | Yes |
Keywords
- Diazeniumdiolates
- Intracavernosal
- Novel nitric oxide donors
- Penile erection
- Transurethral
ASJC Scopus subject areas
- Urology