Induction of penile erection by intracavernosal and transurethral administration of novel nitric oxide donors in the cat

Hunter C. Champion, Trinity Bivalacqua, Run Wang, Philip J. Kadowitz, Larry K. Keefer, Joseph E. Saavedra, Joseph A. Hrabie, Paul C. Doherty, Wayne J G Hellstrom

Research output: Contribution to journalArticle

Abstract

Purpose: The effects of novel nitric oxide (NO) donors administered intracavernosalty and transurethrally on erectile function in the anesthetized cat were evaluated. Materials and Methods: In pentobarbital- anesthetized cats, increases in intracavernosal pressure, penile length, and duration of erectile response were determined after intracavernosal and transurethral injections of novel NO donors (MAHMA/NO, PAPA/NO, DEA/NO, PIPERAZI/NO and PROLI/NO). All parameters were measured after administration of NO donors intracavernosally via a 30-gauge needle and urethrally via a Jelco i.v. catheter in a volume of 200 μl. Systemic arterial pressure was also assessed in these experiments. All NO donors were compared with a triple-drug control combination comprised of papaverine (1.65 mg.), prostaglandin E1 (0.5 μg.), and phentolamine (25 μg.). Results: MAHMA/NO, PAPA/NO, DEA/NO, PIPERAZI/NO and PROLI/NO induced dose dependent increases in intracavernosal pressure and penile length (p

Original languageEnglish (US)
Pages (from-to)2013-2019
Number of pages7
JournalJournal of Urology
Volume161
Issue number6
DOIs
Publication statusPublished - Jun 1999
Externally publishedYes

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Keywords

  • Diazeniumdiolates
  • Intracavernosal
  • Novel nitric oxide donors
  • Penile erection
  • Transurethral

ASJC Scopus subject areas

  • Urology

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