Induction of pancreatic dna damage and nodules in rats treated with n-nitrosobis(2-oxopropyl)amine and n-nitroso(2-hydroxypropyl)(2-oxopropyl)amine

Daniel S. Longnecker, Joanne Zurlo, Thomas J. Curphey, William E. Adams

Research output: Contribution to journalArticlepeer-review

Abstract

DNA damage was demonstrated by alkaline elution analysis in pancreas of rats treated with 100 mg/kg N-nitrosobis(2-oxopropyl)amine (BOP) and 20 mg/kg N-nitroso(2-hydroxy-propyl)2-oxopropyl)amine (HPOP). Young rats were treated with a single dose of BOP or HPOP and autopsied 4 months later. Histologically the pancreases contained multiple foci and nodules of atypical acinar cells which were not seen in controls.

Original languageEnglish (US)
Pages (from-to)715-717
Number of pages3
JournalCarcinogenesis
Volume3
Issue number6
DOIs
StatePublished - Dec 1 1982

ASJC Scopus subject areas

  • Cancer Research

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