Induction of ovulation with cisclomiphene and a placebo

James F. Connaughton, Celso Ramon Garcia, Edward E Wallach

Research output: Contribution to journalArticle


Cisclomiphene, one of the two isomers of clomiphene, has been previously used for induction of ovulation. This paper describes the use of cisclomiphene in 5-nig and dose schedules, and compares its effectiveness to that of a placebo ill a double-blind study. A significant observation was that patients receiving the placebo apparently responded with ovulation as frequently as those subjects given cisclomiphene. In this limited series, cisclomiphene does not appear to be more effective in ovulation induction or in pregnancy rate than clomiphene citrate. The importance oi dose level is pointed out as well as the numerous factors that may be involved in successful use of domiphene-like drugs.

Original languageEnglish (US)
JournalObstetrics and Gynecology
Issue number5
Publication statusPublished - 1974
Externally publishedYes


ASJC Scopus subject areas

  • Obstetrics and Gynecology

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