Induction of mammary carcinomas in rats by nitroso-methylurea involves malignant activation of H-ras-1 locus by single point mutations

Saraswati Sukumar; Vicente Notario; Dionisio Martin-Zanca; Mariano Barbacid

doi:10.1038/306658a0

Induction of mammary carcinomas in rats by nitroso-methylurea involves malignant activation of H-ras-1 locus by single point mutations

Saraswati Sukumar, Vicente Notario, Dionisio Martin-Zanca, Mariano Barbacid

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Abstract

Each of nine mammary carcinomas induced by a single injection of nitroso-methylurea into 50-day-old Buf/N female rats, contained a transforming H-ras-1 gene. Molecular characterization of one of the genes revealed that the twelfth codon was GAA instead of GGA of the normal allele, encoding glutamic acid in place of glycine. These results indicate that chemical carcinogenesis represents an adequate model to study the role of transforming ras genes in human neoplasia.

Original language	English (US)
Pages (from-to)	658-661
Number of pages	4
Journal	Nature
Volume	306
Issue number	5944
DOIs	https://doi.org/10.1038/306658a0
State	Published - Dec 1 1983
Externally published	Yes

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abstract = "Each of nine mammary carcinomas induced by a single injection of nitroso-methylurea into 50-day-old Buf/N female rats, contained a transforming H-ras-1 gene. Molecular characterization of one of the genes revealed that the twelfth codon was GAA instead of GGA of the normal allele, encoding glutamic acid in place of glycine. These results indicate that chemical carcinogenesis represents an adequate model to study the role of transforming ras genes in human neoplasia.",

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AU - Martin-Zanca, Dionisio

AU - Barbacid, Mariano

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Induction of mammary carcinomas in rats by nitroso-methylurea involves malignant activation of H-ras-1 locus by single point mutations

Abstract

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