Induction of macrophage procoagulant activity by murine hepatitis virus strain 3: Role of tyrosine phosphorylation

A. P.B. Dackiw, K. Zakrzewski, A. B. Nathens, P. Y.C. Cheung, R. Fingerote, G. A. Levy, O. D. Rotstein

Research output: Contribution to journalArticle

Abstract

The induction of a unique macrophage procoagulant molecule by routine hepatitis virus strain 3 correlates with the severity of viral hepatitis. The role of tyrosine phosphorylation in the signalling pathway leading to procoagulant expression was studied. Murine hepatitis virus strain 3 initiated a rapid increase in phosphotyrosine accumulation. Tyrosine kinase inhibition precluded this increase and abrogated expression of the virus- induced procoagulant mouse fibrinogen-like protein (musfiblp) gene. These findings suggest that manipulation of this signalling pathway in vivo might represent a novel approach to treating this disease.

Original languageEnglish (US)
Pages (from-to)5824-5828
Number of pages5
JournalJournal of virology
Volume69
Issue number9
DOIs
StatePublished - Sep 1995

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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    Dackiw, A. P. B., Zakrzewski, K., Nathens, A. B., Cheung, P. Y. C., Fingerote, R., Levy, G. A., & Rotstein, O. D. (1995). Induction of macrophage procoagulant activity by murine hepatitis virus strain 3: Role of tyrosine phosphorylation. Journal of virology, 69(9), 5824-5828. https://doi.org/10.1128/jvi.69.9.5824-5828.1995