Induction of HLA-DR antigen on human squamous carcinoma by recombinant interferon gamma

Wayne M. Koch; Elizabeth Dugan; Luis A. Diaz; William J. Richtsmeier

doi:10.1288/00005537-198805000-00007

Induction of HLA-DR antigen on human squamous carcinoma by recombinant interferon gamma

Wayne M. Koch, Elizabeth Dugan, Luis A. Diaz, William J. Richtsmeier

School of Medicine

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The antigen recognition system which plays the major role in immunologic attraction mechanisms, including graft rejection, is the class II major histocompatibility complex containing the HLA-DR locus. Few types of cells constitutively express this antigen, as it is a potent immunological activating signal usually confined to antigen processing cells, activated lymphocytes, and endothelium. Using indirect immunofluorescence, we have observed induction of the HLA-DR glycoprotein in selected head and neck squamous cell carcinoma tissue cultures treated with recombinant interferon gamma. This occurs in concert with growth arrest and morphological changes after rHuIFN-γ treatment. This report describes the induction of a surface antigen that may have profound prognostic significance. Understanding the kinetics of HLA-DR induction will aid in the design and assessment of adoptive immunotherapy with rHuIFN-γ.

Original language	English (US)
Pages (from-to)	511-515
Number of pages	5
Journal	Laryngoscope
Volume	98
Issue number	5
DOIs	https://doi.org/10.1288/00005537-198805000-00007
State	Published - May 1988

ASJC Scopus subject areas

Otorhinolaryngology

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abstract = "The antigen recognition system which plays the major role in immunologic attraction mechanisms, including graft rejection, is the class II major histocompatibility complex containing the HLA-DR locus. Few types of cells constitutively express this antigen, as it is a potent immunological activating signal usually confined to antigen processing cells, activated lymphocytes, and endothelium. Using indirect immunofluorescence, we have observed induction of the HLA-DR glycoprotein in selected head and neck squamous cell carcinoma tissue cultures treated with recombinant interferon gamma. This occurs in concert with growth arrest and morphological changes after rHuIFN-γ treatment. This report describes the induction of a surface antigen that may have profound prognostic significance. Understanding the kinetics of HLA-DR induction will aid in the design and assessment of adoptive immunotherapy with rHuIFN-γ.",

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AU - Richtsmeier, William J.

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AB - The antigen recognition system which plays the major role in immunologic attraction mechanisms, including graft rejection, is the class II major histocompatibility complex containing the HLA-DR locus. Few types of cells constitutively express this antigen, as it is a potent immunological activating signal usually confined to antigen processing cells, activated lymphocytes, and endothelium. Using indirect immunofluorescence, we have observed induction of the HLA-DR glycoprotein in selected head and neck squamous cell carcinoma tissue cultures treated with recombinant interferon gamma. This occurs in concert with growth arrest and morphological changes after rHuIFN-γ treatment. This report describes the induction of a surface antigen that may have profound prognostic significance. Understanding the kinetics of HLA-DR induction will aid in the design and assessment of adoptive immunotherapy with rHuIFN-γ.

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Induction of HLA-DR antigen on human squamous carcinoma by recombinant interferon gamma

Abstract

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