INDUCTION OF GRAFT-VERSUS-HOST DISEASE AFTER AUTOLOGOUS BONE MARROW TRANSPLANTATION

Richard J. Jones, Allan D. Hess, Risa B. Mann, Steven Piantadosi, Georgia B. Vogelsang, Evan R. Farmer, Robert B. Geller, George W. Santos

Research output: Contribution to journalArticlepeer-review

Abstract

To induce graft-versus-host disease (GvHD) in patients undergoing autologous bone marrow transplantation (BMT), five consecutive patients with non-Hodgkin lymphoma or Hodgkin's disease in resistant relapse were treated with cyclophosphamide and total body irradiation or busulphan and cyclophosphamide, followed by autologous BMT. The patients received cyclosporin 1 mg/kg per day intravenously for 28 days after BMT. Histologically proven grade II acute GvHD of the skin developed in all the patients at a median of 11 days (range 9-13) after BMT. One patient died and the GvHD resolved in 1-3 weeks in the four remaining patients- spontaneously in two and with corticosteroid treatment in two. Lymphocytes from one patient obtained at the time of GvHD were cytotoxic for the patient's own pretransplant lymphocytes. Cytotoxicity was blocked by antibodies directed against class II histocompatibility (HLA-DR or Ia) antigens. Cyclosporin-induced GvHD after autologous BMT resembles mild GvHD after allogeneic grafting. This syndrome appears to be mediated by autoreactive Iaspecific lymphocytes.

Original languageEnglish (US)
Pages (from-to)754-757
Number of pages4
JournalThe Lancet
Volume333
Issue number8641
DOIs
StatePublished - Apr 8 1989

ASJC Scopus subject areas

  • Medicine(all)

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