Induction of external abnormalities in offspring of male mice irradiated with 252Cf neutron

Akihiro Kurishita, Tetsuya Ono, Shigefumi Okada, Yuriko Mori, Syozo Sawada

Research output: Contribution to journalArticlepeer-review

Abstract

To assess the genetic effects of fission neutron, the induction of external malformations was studied in F1 fetuses after F0 male mice were irradiated. Male mice of the ICR: MCH strain were irradiated with 252Cf neutron at doses of 0.238, 0.475 and 1.9 Gy. They were mated withnon-irradiated female mice at 71-120 days after the irradiation. Pregnant females were autopsied on day 18 of gestation and their fetuses were examined for deaths and external abnormalities. No increases of pre- and post-implantation losses were noted at any dose. External abnormalities were observed at rates of 1.40% in the 0.238 Gy, 2.23% in the 0.475 Gy, 3.36% in the 0.95 Gy and 3.26% in the 1.9 Gy groups; the rate in the control group was 1.65%. The dose-response curve was linear up to 0.95 Gy, and then flattened out; the induction rate of external abnormalities was 2.7 × 10-4/gamete/cGy based on the linear regression. These results indicated that fission neutron effectively induces external abnormalities in F1 fetuses after spermatogonial irradiation.

Original languageEnglish (US)
Pages (from-to)323-328
Number of pages6
JournalMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume268
Issue number2
DOIs
StatePublished - Aug 1992

Keywords

  • (Mice)
  • Cf neutron
  • Congenital defect
  • External abnormality
  • Spermatogonia

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Health, Toxicology and Mutagenesis

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