Induction of external abnormalities in offspring of male mice irradiated with 252Cf neutron

Akihiro Kurishita, Tetsuya Ono, Shigefumi Okada, Yuriko Mori, Syozo Sawada

Research output: Contribution to journalArticlepeer-review


To assess the genetic effects of fission neutron, the induction of external malformations was studied in F1 fetuses after F0 male mice were irradiated. Male mice of the ICR: MCH strain were irradiated with 252Cf neutron at doses of 0.238, 0.475 and 1.9 Gy. They were mated withnon-irradiated female mice at 71-120 days after the irradiation. Pregnant females were autopsied on day 18 of gestation and their fetuses were examined for deaths and external abnormalities. No increases of pre- and post-implantation losses were noted at any dose. External abnormalities were observed at rates of 1.40% in the 0.238 Gy, 2.23% in the 0.475 Gy, 3.36% in the 0.95 Gy and 3.26% in the 1.9 Gy groups; the rate in the control group was 1.65%. The dose-response curve was linear up to 0.95 Gy, and then flattened out; the induction rate of external abnormalities was 2.7 × 10-4/gamete/cGy based on the linear regression. These results indicated that fission neutron effectively induces external abnormalities in F1 fetuses after spermatogonial irradiation.

Original languageEnglish (US)
Pages (from-to)323-328
Number of pages6
JournalMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Issue number2
StatePublished - Aug 1992


  • (Mice)
  • Cf neutron
  • Congenital defect
  • External abnormality
  • Spermatogonia

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Health, Toxicology and Mutagenesis


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