Induction of donor-specific unresponsiveness by intrathymic islet transplantation

Andrew M. Posselt, Clyde F. Barker, John E. Tomaszewski, James F. Markmann, Michael A. Choti, Ali Naji

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Abstract

The application of isolated pancreatic islet transplantation for treatment of diabetes mellitus has been hampered by the vulnerability of islet allografts to immunologic rejection. Rat islet allografts that were transplanted into the thymus of recipients treated with a single injection of anti-lymphocyte serum survived indefinitely. A state of donor-specific unresponsiveness was achieved that permitted survival of a second donor strain islet allograft transplanted to an extrathymic site. Maturation of T cell precursors in a thymic microenvironment that is harboring foreign alloantigen may induce the selective unresponsiveness. This model provides an approach for pancreatic islet transplantation and a potential strategy for specific modification of the peripheral immune repertoire.

Original languageEnglish (US)
Pages (from-to)1293-1295
Number of pages3
JournalScience
Volume249
Issue number4974
DOIs
StatePublished - Jan 1 1990

ASJC Scopus subject areas

  • General

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    Posselt, A. M., Barker, C. F., Tomaszewski, J. E., Markmann, J. F., Choti, M. A., & Naji, A. (1990). Induction of donor-specific unresponsiveness by intrathymic islet transplantation. Science, 249(4974), 1293-1295. https://doi.org/10.1126/science.2119056