Induction of collagenase synthesis in chondrocytes by a factor synthesized by inflamed synovial tissue

S. S. Kerwar; Susan C. Ridge; M. Jane Landes; Joseph C. Nolan; Arnold L. Oronsky

doi:10.1007/BF01986690

Induction of collagenase synthesis in chondrocytes by a factor synthesized by inflamed synovial tissue

S. S. Kerwar, Susan C. Ridge, M. Jane Landes, Joseph C. Nolan, Arnold L. Oronsky

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Rabbit inflamed synovial tissue grown in culture synthesizes a factor that induces collagenase synthesis in chondrocytes and in cartilage. Synthesis of this factor by the synovial tissue is inhibited by cycloheximide but not by indomethacin. The factor has an apparent molecular weight of 30,000, is stable to heat and to trypsin treatment but is inactivated by acid. Induction of collagenase synthesis in chondrocytes occurs after a lag period of 6 hours.

Original language	English (US)
Pages (from-to)	206-210
Number of pages	5
Journal	Agents and Actions
Volume	43
Issue number	3-4
DOIs	https://doi.org/10.1007/BF01986690
State	Published - Dec 1 1994

ASJC Scopus subject areas

Toxicology
Pharmacology (medical)

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abstract = "Rabbit inflamed synovial tissue grown in culture synthesizes a factor that induces collagenase synthesis in chondrocytes and in cartilage. Synthesis of this factor by the synovial tissue is inhibited by cycloheximide but not by indomethacin. The factor has an apparent molecular weight of 30,000, is stable to heat and to trypsin treatment but is inactivated by acid. Induction of collagenase synthesis in chondrocytes occurs after a lag period of 6 hours.",

author = "Kerwar, {S. S.} and Ridge, {Susan C.} and Landes, {M. Jane} and Nolan, {Joseph C.} and Oronsky, {Arnold L.}",

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AU - Kerwar, S. S.

AU - Ridge, Susan C.

AU - Landes, M. Jane

AU - Nolan, Joseph C.

AU - Oronsky, Arnold L.

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N2 - Rabbit inflamed synovial tissue grown in culture synthesizes a factor that induces collagenase synthesis in chondrocytes and in cartilage. Synthesis of this factor by the synovial tissue is inhibited by cycloheximide but not by indomethacin. The factor has an apparent molecular weight of 30,000, is stable to heat and to trypsin treatment but is inactivated by acid. Induction of collagenase synthesis in chondrocytes occurs after a lag period of 6 hours.

AB - Rabbit inflamed synovial tissue grown in culture synthesizes a factor that induces collagenase synthesis in chondrocytes and in cartilage. Synthesis of this factor by the synovial tissue is inhibited by cycloheximide but not by indomethacin. The factor has an apparent molecular weight of 30,000, is stable to heat and to trypsin treatment but is inactivated by acid. Induction of collagenase synthesis in chondrocytes occurs after a lag period of 6 hours.

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Induction of collagenase synthesis in chondrocytes by a factor synthesized by inflamed synovial tissue

Abstract

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