Induction of CD4+ human cytolytic T cells specific for HIV-infected cells by a gp160 subunit vaccine

Rimas J. Orentas, James E.K. Hildreth, Eugene Obah, Michael Polydefkis, Gale E. Smith, Mary Lou Clements, Robert F. Siliciano

Research output: Contribution to journalArticlepeer-review

Abstract

Cytolytic T lymphocyte (CTL) responses were evaluated in humans immunized with recombinant human immunodeficiency virus type 1 (HIV) envelope glycoprotein gp160. Some vaccinees had gpl60-specific CTLs that were shown by cloning to be CD4+. Although induced by exogenous antigen, most gpl60-specific CTL clones also recognized gp160 synthesized endogenously in target cells. These clones lysed autologous CD4+ T lymphoblasts infected with HIV. Of particular interest were certain vaccine-induced clones that lysed HIV-infected cells, recognized gpl60 from diverse HIV isolates, and did not participate in "innocent bystander" killing of noninfected CD4+ T cells that had bound gpl20.

Original languageEnglish (US)
Pages (from-to)1234-1237
Number of pages4
JournalScience
Volume248
Issue number4960
DOIs
StatePublished - 1990

ASJC Scopus subject areas

  • General

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