Induction of antigen-specific T cell anergy: An early event in the course of tumor progression

Kevin Staveley-O'Carroll, Eduardo Sotomayor, Jami Montgomery, Ivan Borrello, Leon Hwang, Steve Fein, Drew Pardoll, Hyam Levitsky

Research output: Contribution to journalArticle

Abstract

The priming of tumor-antigen-specific T cells is critical for the initiation of successful anti-tumor immune responses, yet the fate of such cells during tumor progression is unknown. Naive CD4+ T cells specific for an antigen expressed by tumor cells were transferred into tumor-bearing mice. Transient clonal expansion occurred early after transfer, accompanied by phenotypic changes associated with antigen recognition. Nevertheless, these cells had a diminished response to peptide antigen in vitro and were unable to be primed in vivo. The development of antigen-specific T cell anergy is an early event in the tumor-bearing host, and it suggests that tolerance to tumor antigens may impose a significant barrier to therapeutic vaccination.

Original languageEnglish (US)
Pages (from-to)1178-1183
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume95
Issue number3
DOIs
StatePublished - Feb 3 1998

ASJC Scopus subject areas

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