TY - JOUR
T1 - Induction of antigen-specific T cell anergy
T2 - An early event in the course of tumor progression
AU - Staveley-O'Carroll, Kevin
AU - Sotomayor, Eduardo
AU - Montgomery, Jami
AU - Borrello, Ivan
AU - Hwang, Leon
AU - Fein, Steve
AU - Pardoll, Drew
AU - Levitsky, Hyam
PY - 1998/2/3
Y1 - 1998/2/3
N2 - The priming of tumor-antigen-specific T cells is critical for the initiation of successful anti-tumor immune responses, yet the fate of such cells during tumor progression is unknown. Naive CD4+ T cells specific for an antigen expressed by tumor cells were transferred into tumor-bearing mice. Transient clonal expansion occurred early after transfer, accompanied by phenotypic changes associated with antigen recognition. Nevertheless, these cells had a diminished response to peptide antigen in vitro and were unable to be primed in vivo. The development of antigen-specific T cell anergy is an early event in the tumor-bearing host, and it suggests that tolerance to tumor antigens may impose a significant barrier to therapeutic vaccination.
AB - The priming of tumor-antigen-specific T cells is critical for the initiation of successful anti-tumor immune responses, yet the fate of such cells during tumor progression is unknown. Naive CD4+ T cells specific for an antigen expressed by tumor cells were transferred into tumor-bearing mice. Transient clonal expansion occurred early after transfer, accompanied by phenotypic changes associated with antigen recognition. Nevertheless, these cells had a diminished response to peptide antigen in vitro and were unable to be primed in vivo. The development of antigen-specific T cell anergy is an early event in the tumor-bearing host, and it suggests that tolerance to tumor antigens may impose a significant barrier to therapeutic vaccination.
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U2 - 10.1073/pnas.95.3.1178
DO - 10.1073/pnas.95.3.1178
M3 - Article
C2 - 9448305
AN - SCOPUS:0032477815
SN - 0027-8424
VL - 95
SP - 1178
EP - 1183
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 3
ER -