Induction of alpha interferon by human immunodeficiency virus type 1 in human monocyte-macrophage cultures

J. Szebeni, C. Dieffenbach, S. M. Wahl, C. N. Venkateshan, A. Yeh, M. Popovic, S. Gartner, L. M. Wahl, M. Peterfy, R. M. Friedman, J. N. Weinstein

Research output: Contribution to journalArticlepeer-review

Abstract

The induction of interferon (IFN) by human immunodeficiency virus type 1 (HIV-1) in primary, nonstimulated monocyte-macrophage cultures was studied. HIV-1 infection, as confirmed by p24 antigen levels in the cell supernatant, led to the production of alpha interferon (IFN-α) over 7 to 21 days following infection. In two of seven experiments, the IFN detected was acid labile. Coupled reverse transcription-polymerase chain reaction analysis confirmed the induction of IFN-α mRNA in cells of HIV-1-infected cultures.

Original languageEnglish (US)
Pages (from-to)6362-6364
Number of pages3
JournalJournal of Virology
Volume65
Issue number11
StatePublished - Nov 1991
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

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