Induction and maintenance of protective CD8 + T cells against malaria liver stages: Implications for vaccine development

Sze Wah Tse, Andrea J. Radtke, Fidel Zavala

Research output: Contribution to journalArticle

Abstract

CD8 + T cells against malaria liver stages represent a major protective immune mechanism against infection. Following induction in the peripheral lymph nodes by dendritic cells (DCs), these CD8 + T cells migrate to the liver and eliminate parasite infected hepatocytes. The processing and presentation of sporozoite antigen requires TAP mediated transport of major histocompatibility complex class I epitopes to the endoplasmic reticulum. Importantly, in DCs this process is also dependent on endosome-mediated cross presentation while this mechanism is not required for epitope presentation on hepatocytes. Protective CD8 + T cell responses are strongly dependent on the presence of CD4 + T cells and the capacity of sporozoite antigen to persist for a prolonged period of time. While human trials with subunit vaccines capable of inducing antibodies and CD4 + T cell responses have yielded encouraging results, an effective anti-malaria vaccine will likely require vaccine constructs designed to induce protective CD8 + T cells against malaria liver stages.

Original languageEnglish (US)
Pages (from-to)172-178
Number of pages7
JournalMemorias do Instituto Oswaldo Cruz
Volume106
Issue numberSUPPL. 1
DOIs
StatePublished - Aug 2011

Keywords

  • CD8 T cell
  • Malaria
  • Sporozoites
  • Vaccine

ASJC Scopus subject areas

  • Microbiology (medical)

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