Inducible nitric oxide synthase protection against Coxsackievirus pancreatitis

Carlos Zaragoza, Christopher J. Ocampo, Marta Saura, Clare Bao, Michelle Leppo, Anne Lafond-Walker, David R. Thiemann, Ralph Hruban, Charles J. Lowenstein

Research output: Contribution to journalArticlepeer-review

Abstract

Coxsackievirus infection causes myocarditis and pancreatitis in humans. In certain strains of mice, Coxsackievirus causes a severe pancreatitis. We explored the role of NO in the host immune response to viral pancreatitis. Coxsackievirus replicates to higher titers in mice lacking NO synthase 2 (NOS2) than in wild-type mice, with particularly high viral titers and viral RNA levels in the pancreas. Mice lacking NOS have a severe, necrotizing pancreatitis, with elevated pancreatic enzymes in the blood and necrotic acinar cells. Lack of NOS2 leads to a rapid increase in the mortality of infected mice. Thus, NOS2 is a critical component in the immune response to Coxsackievirus infection.

Original languageEnglish (US)
Pages (from-to)5497-5504
Number of pages8
JournalJournal of Immunology
Volume163
Issue number10
StatePublished - Nov 15 1999

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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