TY - JOUR
T1 - Inducible nitric oxide synthase protection against Coxsackievirus pancreatitis
AU - Zaragoza, Carlos
AU - Ocampo, Christopher J.
AU - Saura, Marta
AU - Bao, Clare
AU - Leppo, Michelle
AU - Lafond-Walker, Anne
AU - Thiemann, David R.
AU - Hruban, Ralph
AU - Lowenstein, Charles J.
PY - 1999/11/15
Y1 - 1999/11/15
N2 - Coxsackievirus infection causes myocarditis and pancreatitis in humans. In certain strains of mice, Coxsackievirus causes a severe pancreatitis. We explored the role of NO in the host immune response to viral pancreatitis. Coxsackievirus replicates to higher titers in mice lacking NO synthase 2 (NOS2) than in wild-type mice, with particularly high viral titers and viral RNA levels in the pancreas. Mice lacking NOS have a severe, necrotizing pancreatitis, with elevated pancreatic enzymes in the blood and necrotic acinar cells. Lack of NOS2 leads to a rapid increase in the mortality of infected mice. Thus, NOS2 is a critical component in the immune response to Coxsackievirus infection.
AB - Coxsackievirus infection causes myocarditis and pancreatitis in humans. In certain strains of mice, Coxsackievirus causes a severe pancreatitis. We explored the role of NO in the host immune response to viral pancreatitis. Coxsackievirus replicates to higher titers in mice lacking NO synthase 2 (NOS2) than in wild-type mice, with particularly high viral titers and viral RNA levels in the pancreas. Mice lacking NOS have a severe, necrotizing pancreatitis, with elevated pancreatic enzymes in the blood and necrotic acinar cells. Lack of NOS2 leads to a rapid increase in the mortality of infected mice. Thus, NOS2 is a critical component in the immune response to Coxsackievirus infection.
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M3 - Article
C2 - 10553076
AN - SCOPUS:0033571461
VL - 163
SP - 5497
EP - 5504
JO - Journal of Immunology
JF - Journal of Immunology
SN - 0022-1767
IS - 10
ER -