Inducible nitric oxide synthase expression inhibition by adenovirus E1A

Wangsen Cao, Clare Bao, Charles J. Lowenstein

Research output: Contribution to journalArticle

Abstract

Nitric oxide (NO) is an antiviral effector of the innate immune system. Viruses that can interfere with NO synthesis may be able to replicate more rapidly than viruses that cannot limit NO synthesis. We show that the adenovirus E1A protein inhibits NO production by decreasing expression of the inducible NO synthase (NOS2). The amino-terminal portion of E1A decreases transactivation of the NOS2 5′-flanking region, limiting the DNA binding activity of NF-κB and inhibiting NOS2 expression. E1A is thus able to deactivate a critical component of the host defense against viral infection. Viral inhibition of NO production is a mechanism that may enable certain viruses to evade the host innate immune system.

Original languageEnglish (US)
Pages (from-to)7773-7778
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume100
Issue number13
DOIs
StatePublished - Jun 24 2003

Keywords

  • Histone acetyltransferase
  • IFN
  • NF-κB
  • Peroxynitrite
  • Transcription

ASJC Scopus subject areas

  • General

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