Inducer T lymphocytes synthesize a factor that stimulates proliferation of cloned mast cells

Gary Nabel, Stephen J. Galli, Ann M. Dvorak, Harold F. Dvorak, Harvey Cantor

Research output: Contribution to journalArticle

Abstract

Inducer T lymphocytes activate other cells to divide and express new function. Known target cells include other lymphocytes and haematopoietic stem cells1. We now provide evidence that the inducer T cell acts on another important target population: mast cells. Mast cells have a central role in the expression of immediate hypersensitivity and are also prominent in T-cell mediated reactions of the delayed type2-7. Because the proliferation of differentiated cells is often regulated by soluble growth factors, we examined an inducer T-cell clone for its ability to stimulate mast cell proliferation. We report here that cloned Ly1+2- inducer T cells produce a factor that selectively induces morphologically and karyotypically normal mouse mast cell clones to proliferate. We therefore suggest that inducer T cells may regulate mast cell numbers by releasing a soluble growth factor that stimulates them to divide. Because mast cell products also affect certain T-cell functions8-10, mast cell-T cell interactions may comprise part of an immunoregulatory circuit.

Original languageEnglish (US)
Pages (from-to)332-334
Number of pages3
JournalNature
Volume291
Issue number5813
DOIs
StatePublished - 1981
Externally publishedYes

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Helper-Inducer T-Lymphocytes
Mast Cells
T-Lymphocytes
Intercellular Signaling Peptides and Proteins
Clone Cells
Cell Proliferation
Immediate Hypersensitivity
Health Services Needs and Demand
Cell Communication
Cell Count
Lymphocytes

ASJC Scopus subject areas

  • General

Cite this

Nabel, G., Galli, S. J., Dvorak, A. M., Dvorak, H. F., & Cantor, H. (1981). Inducer T lymphocytes synthesize a factor that stimulates proliferation of cloned mast cells. Nature, 291(5813), 332-334. https://doi.org/10.1038/291332a0

Inducer T lymphocytes synthesize a factor that stimulates proliferation of cloned mast cells. / Nabel, Gary; Galli, Stephen J.; Dvorak, Ann M.; Dvorak, Harold F.; Cantor, Harvey.

In: Nature, Vol. 291, No. 5813, 1981, p. 332-334.

Research output: Contribution to journalArticle

Nabel, G, Galli, SJ, Dvorak, AM, Dvorak, HF & Cantor, H 1981, 'Inducer T lymphocytes synthesize a factor that stimulates proliferation of cloned mast cells', Nature, vol. 291, no. 5813, pp. 332-334. https://doi.org/10.1038/291332a0
Nabel, Gary ; Galli, Stephen J. ; Dvorak, Ann M. ; Dvorak, Harold F. ; Cantor, Harvey. / Inducer T lymphocytes synthesize a factor that stimulates proliferation of cloned mast cells. In: Nature. 1981 ; Vol. 291, No. 5813. pp. 332-334.
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