TY - JOUR
T1 - Indoor air pollution exposure is associated with greater morbidity in cystic fibrosis
AU - Carson, Sara W.
AU - Psoter, Kevin
AU - Koehler, Kirsten
AU - Siklosi, Karen R.
AU - Montemayor, Kristina
AU - Toporek, Alexandra
AU - West, Natalie E.
AU - Lechtzin, Noah
AU - Hansel, Nadia N.
AU - Collaco, Joseph M.
AU - Merlo, Christian A.
N1 - Funding Information:
The authors would like to thank Garry R. Cutting, M.D. Professor of Genetic Medicine at Johns Hopkins School of Medicine and the primary investigator on the US Twin and Sibling Study, for permission to use the data collected for the US Twin and Sibling Study for this manuscript. SWC and CAM contributed to the conception and authorship of this manuscript. KP conducted the statistical analysis and provided revisions for this manuscript. KK provided environmental expertise regarding sources of indoor air pollution and their effects on health. KRS provided substantial support in data management of the Twin and Sibling Study database. KM provided substantial revisions to this manuscript. AT provided substantial revisions to this manuscript. NEW and NL provided substantial support during the conception of this manuscript and provided substantial revisions to the manuscript. NNH provided expertise indoor air pollution effects on chronic lung disease as well as provided substantial revisions to this manuscript. JMC, one of the main investigators on the Twin Sibling Study, provided the data available for this manuscript and provided substantial guidance and revisions to this manuscript. All authors reviewed and approved the manuscript prior to submission for this publication. Sara Carson: Conceptualization, writing- original draft, funding acquisition, methodology. Kevin Psoter: methodology, formal analysis. Kirsten Koehler: writing – review and editing, Karen Siklosi: data curation. Kristina Montemayor: writing-review and editing. Alexandra Toporek: writing-review and editing. Natalie West: conceptualization, writing-review and editing. Noah Lechtzin: conceptualization, writing-review and editing. Nadia Hansel: conceptualization, writing-review and editing. Joseph Callaco: conceptualization, resources, methodology, investigation, supervision. Christian Merlo: conceptualization, methodology, writing-review and editing, supervision. Selected portions of this manuscript were presented at the American Thoracic Society (ATS) 2019 International Conference in Dallas, TX in May 2019, as well as the 33rd Annual North American Cystic Fibrosis Conference (NACFC) in Nashville, Tennessee in November 2019. This work was supported by the National Heart, Lung, And Blood Institute of the NIH award numbers F32HL149262 (SWC) and R01-HL128475 (JMC) and by the Cystic Fibrosis Foundation award numbers CARSON19B0 and CUTTIN18XX1 (GR Cutting).
Funding Information:
This work was supported by the National Heart, Lung, And Blood Institute of the NIH award numbers F32HL149262 ( SWC ) and R01-HL128475 ( JMC ) and by the Cystic Fibrosis Foundation award numbers CARSON19B0 and CUTTIN18XX1 (GR Cutting).
Publisher Copyright:
© 2021
PY - 2022/3
Y1 - 2022/3
N2 - Background: Exposure to higher levels of outdoor air pollution is associated with increased morbidity in individuals with cystic fibrosis. Limited information exist regarding the potential adverse effects of indoor air pollution on those with cystic fibrosis. Methods: Individuals with cystic fibrosis who were enrolled in the Twin and Sibling Study from 2000-2013, self-reported exposure to four known sources of indoor air pollution (secondhand smoke, forced hot air, wood stove and fireplace). Change in lung function, rates of hospitalizations and pulmonary exacerbations were followed over 4 years to compare outcomes in those who were exposed to those who were not exposed. Results: Of 1432 participants with data on secondhand smoke exposure, 362 (25.3%) were exposed. Of 765 individuals with data on forced hot air exposure, 491 (64.2%) were exposed. Of 1247 participants with data on wood stove exposure and 830 with data on fireplace exposure, 182 (14.6%) and 373 (44.9%) were exposed, respectively. In longitudinal analysis, pediatric individuals either exposed to secondhand smoke or to forced hot air had a 0.60% predicted/year decrease in FEV1% predicted (P=0.002) or a 0.46% predicted/year decrease in FEV1% predicted (P=0.048), respectively compared to individuals who were not exposed. Adults exposed to secondhand smoke had a 42% increased yearly risk of hospitalization compared to those who were not exposed (P=0.045). Conclusions: Our questionnaire-based data suggest that exposure to sources of indoor air pollution increase morbidity in both the pediatric and adult cystic fibrosis populations. Future studies with quantitative indoor air quality assessments are needed.
AB - Background: Exposure to higher levels of outdoor air pollution is associated with increased morbidity in individuals with cystic fibrosis. Limited information exist regarding the potential adverse effects of indoor air pollution on those with cystic fibrosis. Methods: Individuals with cystic fibrosis who were enrolled in the Twin and Sibling Study from 2000-2013, self-reported exposure to four known sources of indoor air pollution (secondhand smoke, forced hot air, wood stove and fireplace). Change in lung function, rates of hospitalizations and pulmonary exacerbations were followed over 4 years to compare outcomes in those who were exposed to those who were not exposed. Results: Of 1432 participants with data on secondhand smoke exposure, 362 (25.3%) were exposed. Of 765 individuals with data on forced hot air exposure, 491 (64.2%) were exposed. Of 1247 participants with data on wood stove exposure and 830 with data on fireplace exposure, 182 (14.6%) and 373 (44.9%) were exposed, respectively. In longitudinal analysis, pediatric individuals either exposed to secondhand smoke or to forced hot air had a 0.60% predicted/year decrease in FEV1% predicted (P=0.002) or a 0.46% predicted/year decrease in FEV1% predicted (P=0.048), respectively compared to individuals who were not exposed. Adults exposed to secondhand smoke had a 42% increased yearly risk of hospitalization compared to those who were not exposed (P=0.045). Conclusions: Our questionnaire-based data suggest that exposure to sources of indoor air pollution increase morbidity in both the pediatric and adult cystic fibrosis populations. Future studies with quantitative indoor air quality assessments are needed.
KW - Indoor air quality
KW - Obstructive lung disease
KW - Secondhand smoke
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U2 - 10.1016/j.jcf.2021.08.015
DO - 10.1016/j.jcf.2021.08.015
M3 - Article
C2 - 34531156
AN - SCOPUS:85116375438
VL - 21
SP - e129-e135
JO - Journal of Cystic Fibrosis
JF - Journal of Cystic Fibrosis
SN - 1569-1993
IS - 2
ER -