Indomethacin modification of immediate-type immunologic airway responses in allergic asthmatic and non-asthmatic subjects. Evidence for altered arachidonic acid metabolism in asthma

J. E. Fish, M. G. Ankin, N. F. Adkinson, V. I. Peterman

Research output: Contribution to journalArticlepeer-review

Abstract

To examine the role of arachidonic acid metabolism in the modulation of immediate-type immunologic airway responses, we compared the effects of indomethacin (50 mg every 6 h for 96 h) and placebo on responses to antigen inhalation challenge in allergic asthmatic subjects and a group of nonasthmatic subjects with allergic rhinitis. Sensitivity to antigen was determined for changes in one-second forced expiratory volume, specific airway conductance, and expiratory flow at 25% of the forced vital capacity measured from partial flow-volume curves. The groups differed in terms of prechallenge pulmonary function and non-immunologic airway reactivity as determined by methacholine challenge, but were comparable with respect to intradermal sensitivity to ragweed antigen. After placebo, asthmatic subjects demonstrated approximately 3.5-fold greater sensitivity to antigen than that of nonasthmatic subjects. Indomethacin had no effect on prechallenge pulmonary function in either group. However, after indomethacin, non-asthmatic subjects had a significant increase in antigen sensitivity. Indomethacin had no effect on antigen sensitivity in asthmatic subjects as measured by one-second forced expiratory volume or expiratory flow at 25% of the forced vital capacity, and produced a slight but significant decrease as measured by specific airway conductance. Indomethacin failed to alter methacholine sensitivity in atopic, non-asthmatic subjects. These findings indicate that products of arachidonic acid metabolism participates in vivo in the modulation of airway responses to immediate-type immunologic stimuli, and that this participation differs in asthmatic and nonasthmatic subjects.

Original languageEnglish (US)
Pages (from-to)609-614
Number of pages6
JournalAmerican Review of Respiratory Disease
Volume123
Issue number6
StatePublished - Jan 1 1981

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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