Individual and partner risk factors associated with abnormal cervical cytology among women in HIV-discordant relationships

Jason Soh, Anne F. Rositch, Laura Koutsky, Brandon L. Guthrie, Robert Y. Choi, Rose K. Bosire, Ann Gatuguta, Jennifer S. Smith, James Kiarie, Barbara Lohman-Payne, Carey Farquhar

Research output: Contribution to journalArticlepeer-review

Abstract

Individual and sexual partner characteristics may increase the risk of abnormal cervical cytology among women in human immunodeficiency virus (HIV)-discordant relationships. Papanicolaou smears were obtained in a prospective cohort of Kenyan HIV-discordant couples. Of 441 women, 283 (64%) were HIV-infected and 158 (36%) were HIV-uninfected with HIV-infected partners. Overall, 79 (18%) had low-grade and 25 (6%) high-grade cervical abnormalities. Male herpes simplex virus type 2 (HSV-2) seropositivity and lower couple socioeconomic status were associated with cervical abnormalities (p < 0.05). HIV-uninfected women with HIV-infected male sex partners (CD4 > 350 cells/μL) had the lowest prevalence of high-grade cervical lesions. HIV-infected women (CD4 > 350 cells/μL) and HIV-uninfected women with HIV-infected partners (CD4 ≤ 350 cells/μL) were at similar intermediate risk (p > 0.05), and HIV-infected women (CD4 ≤ 350 cells/μL) had significantly higher risk of high-grade cervical abnormalities (p = 0.05). Women in HIV-discordant relationships have high rates of cervical lesions and this may be influenced by couple-level factors, including HIV status and CD4 count of the infected partner.

Original languageEnglish (US)
Pages (from-to)315-324
Number of pages10
JournalInternational Journal of STD and AIDS
Volume25
Issue number5
DOIs
StatePublished - Apr 2014
Externally publishedYes

Keywords

  • AIDS
  • Africa
  • HIV
  • HPV
  • cervical cancer
  • cervical intraepithelial neoplasia
  • cytology
  • discordant couples
  • human papillomavirus
  • sexually transmitted infection

ASJC Scopus subject areas

  • Dermatology
  • Public Health, Environmental and Occupational Health
  • Pharmacology (medical)
  • Infectious Diseases

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