Indirect effect of conjugate vaccine on adult carriage of Streptococcus pneumoniae: An explanation of trends in invasive pneumococcal disease

Laura L Hammitt, Dana L. Bruden, Jay C. Butler, Henry C. Baggett, Debby A. Hurlburt, Alisa Reasonover, Thomas W. Hennessy

Research output: Contribution to journalArticle

Abstract

Background. Use of heptavalent protein-polysaccharide pneumococcal conjugate vaccine (PCV7) has been associated with decreases in PCV7-type invasive pneumococcal disease and nasopharyngeal (NP) carriage in children. Vaccine use has also indirectly decreased the rate of invasive disease in adults, presumably through decreased transmission of pneumococci from vaccinated children to adults. Methods. We conducted NP carriage surveys in 8 villages in Alaska in 1998-2004. Streptococcus pneumoniae isolates were characterized by serotype and antimicrobial susceptibility. We analyzed trends in serotype distribution, antibiotic resistance, and factors associated with adult carriage of PCV7-serotype pneumococci before and after the introduction of PCV7 in 2001. Results. We collected 15,598 NP swabs; overall, 52% of adults living in the villages surveyed participated in the colonization study. The proportion of adult carriers with PCV7-type pneumococcal carriage decreased from 28% of carriers in 1998-2000 to 4.5% of carriers in 2004 (P

Original languageEnglish (US)
Pages (from-to)1487-1494
Number of pages8
JournalJournal of Infectious Diseases
Volume193
Issue number11
DOIs
StatePublished - Jun 1 2006
Externally publishedYes

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Conjugate Vaccines
Streptococcus pneumoniae
Nasopharyngeal Diseases
Pneumococcal Vaccines
R Factors
Microbial Drug Resistance
Polysaccharides
Vaccines
Serogroup
Proteins

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

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Indirect effect of conjugate vaccine on adult carriage of Streptococcus pneumoniae : An explanation of trends in invasive pneumococcal disease. / Hammitt, Laura L; Bruden, Dana L.; Butler, Jay C.; Baggett, Henry C.; Hurlburt, Debby A.; Reasonover, Alisa; Hennessy, Thomas W.

In: Journal of Infectious Diseases, Vol. 193, No. 11, 01.06.2006, p. 1487-1494.

Research output: Contribution to journalArticle

Hammitt, Laura L ; Bruden, Dana L. ; Butler, Jay C. ; Baggett, Henry C. ; Hurlburt, Debby A. ; Reasonover, Alisa ; Hennessy, Thomas W. / Indirect effect of conjugate vaccine on adult carriage of Streptococcus pneumoniae : An explanation of trends in invasive pneumococcal disease. In: Journal of Infectious Diseases. 2006 ; Vol. 193, No. 11. pp. 1487-1494.
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AU - Reasonover, Alisa

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