Abstract
Objectives: Secondary prevention trials in subjects with preclinical Alzheimer disease may require documentation of brain amyloidosis. The identification of inexpensive and noninvasive screening variables that can identify individuals who have significant amyloid accumulation would reduce screening costs. Methods: A total of 483 cognitively normal (CN) individuals, aged 70-92 years, from the population-based Mayo Clinic Study of Aging, underwent Pittsburgh compound B (PiB)-PET imaging. Logistic regression determined whether age, sex, APOE genotype, family history, or cognitive performance was associated with odds of a PiB retention ratio
Original language | English (US) |
---|---|
Pages (from-to) | 1570-1577 |
Number of pages | 8 |
Journal | Neurology |
Volume | 79 |
Issue number | 15 |
DOIs | |
State | Published - Oct 9 2012 |
Externally published | Yes |
ASJC Scopus subject areas
- Clinical Neurology
- Arts and Humanities (miscellaneous)