Indicators of amyloid burden in a population-based study of cognitively normal elderly

Michelle M. Mielke, Heather J. Wiste, Stephen D. Weigand, David S. Knopman, Val J. Lowe, Rosebud O. Roberts, Yonas E. Geda, Dana M. Swenson-Dravis, Bradley F. Boeve, Matthew L. Senjem, Prashanthi Vemuri, Ronald C. Petersen, Clifford R. Jack

Research output: Contribution to journalArticle

Abstract

Objectives: Secondary prevention trials in subjects with preclinical Alzheimer disease may require documentation of brain amyloidosis. The identification of inexpensive and noninvasive screening variables that can identify individuals who have significant amyloid accumulation would reduce screening costs. Methods: A total of 483 cognitively normal (CN) individuals, aged 70-92 years, from the population-based Mayo Clinic Study of Aging, underwent Pittsburgh compound B (PiB)-PET imaging. Logistic regression determined whether age, sex, APOE genotype, family history, or cognitive performance was associated with odds of a PiB retention ratio

Original languageEnglish (US)
Pages (from-to)1570-1577
Number of pages8
JournalNeurology
Volume79
Issue number15
DOIs
StatePublished - Oct 9 2012
Externally publishedYes

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Amyloid
Amyloidosis
Secondary Prevention
Documentation
Population
Alzheimer Disease
Logistic Models
Genotype
Costs and Cost Analysis
Brain
2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole
Burden
Pittsburgh
Screening
Family History
Clinic
Imaging
Cognitive Performance
Logistic Regression
Costs

ASJC Scopus subject areas

  • Clinical Neurology
  • Arts and Humanities (miscellaneous)

Cite this

Mielke, M. M., Wiste, H. J., Weigand, S. D., Knopman, D. S., Lowe, V. J., Roberts, R. O., ... Jack, C. R. (2012). Indicators of amyloid burden in a population-based study of cognitively normal elderly. Neurology, 79(15), 1570-1577. https://doi.org/10.1212/WNL.0b013e31826e2696

Indicators of amyloid burden in a population-based study of cognitively normal elderly. / Mielke, Michelle M.; Wiste, Heather J.; Weigand, Stephen D.; Knopman, David S.; Lowe, Val J.; Roberts, Rosebud O.; Geda, Yonas E.; Swenson-Dravis, Dana M.; Boeve, Bradley F.; Senjem, Matthew L.; Vemuri, Prashanthi; Petersen, Ronald C.; Jack, Clifford R.

In: Neurology, Vol. 79, No. 15, 09.10.2012, p. 1570-1577.

Research output: Contribution to journalArticle

Mielke, MM, Wiste, HJ, Weigand, SD, Knopman, DS, Lowe, VJ, Roberts, RO, Geda, YE, Swenson-Dravis, DM, Boeve, BF, Senjem, ML, Vemuri, P, Petersen, RC & Jack, CR 2012, 'Indicators of amyloid burden in a population-based study of cognitively normal elderly', Neurology, vol. 79, no. 15, pp. 1570-1577. https://doi.org/10.1212/WNL.0b013e31826e2696
Mielke MM, Wiste HJ, Weigand SD, Knopman DS, Lowe VJ, Roberts RO et al. Indicators of amyloid burden in a population-based study of cognitively normal elderly. Neurology. 2012 Oct 9;79(15):1570-1577. https://doi.org/10.1212/WNL.0b013e31826e2696
Mielke, Michelle M. ; Wiste, Heather J. ; Weigand, Stephen D. ; Knopman, David S. ; Lowe, Val J. ; Roberts, Rosebud O. ; Geda, Yonas E. ; Swenson-Dravis, Dana M. ; Boeve, Bradley F. ; Senjem, Matthew L. ; Vemuri, Prashanthi ; Petersen, Ronald C. ; Jack, Clifford R. / Indicators of amyloid burden in a population-based study of cognitively normal elderly. In: Neurology. 2012 ; Vol. 79, No. 15. pp. 1570-1577.
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