Indeterminate colitis: A significant subgroup of pediatric IBD

Ryan S. Carvalho, Vivian Abadom, Harrison P. Dilworth, Richard Thompson, Maria Oliva-Hemker, Carmen Cuffari

Research output: Contribution to journalArticle

Abstract

Background: Indeterminate colitis (IC) is a subgroup of inflammatory bowel disease (IBD) that cannot be characterized as either ulcerative colitis (UC) or Crohn's disease (CD). Our aims are to determine the prevalence of IC in our pediatric patient population and to describe its clinical presentation, natural history,and disease distribution. Methods: We performed a retrospective database analysis of all children diagnosed with IBD at the Johns Hopkins Children's IBD Center between 1996 and 2001. Patient demographics, including age, sex, and age at disease onset, were tallied. Disease distribution was identified on the basis of a review of all endoscopic, colonoscopic, histopathological, and radiological records. All of the patients were followed up clinically to determine the extent of disease progression on the basis of the initial diagnosis of IC. Results: Among 250 children registered in the database, 127 (50.8%) had a diagnosis of CD, 49 (19.6%) had UC, and 74 (29.6%) had IC. Patients with IC had a significantly younger mean ± SEM age (9.53 ± 4.8 years) at diagnosis compared with patients with CD (12.4 ± 3.8 years; P < 0.001) but not compared with patients with UC (7.41 ± 3.5 years). Among the patients with IC, 59 (79.7%) had a pancolitis at diagnosis, and the remaining 15 had left-sided disease that progressed to a pancolitis within a mean of 6 years. Twenty-five patients (33.7%) with an initial diagnosis of IC were reclassified to either CD or UC after a median follow-up of 1.9 years (range 0.6-4.5 years). Forty-nine patients (66.2%) maintained their diagnosis of IC after a mean follow-up of 7 years (SEM 2.5 years). Conclusions: IC is a distinct pediatric subgroup of IBD with a prevalence that is higher than that observed in adults. Children with IC have an early age of disease onset and a disease that rapidly progresses to pancolitis. Longitudinal studies are needed to determine the clinical implications of this pediatric IBD subgroup.

Original languageEnglish (US)
Pages (from-to)258-262
Number of pages5
JournalInflammatory bowel diseases
Volume12
Issue number4
DOIs
StatePublished - Apr 1 2006

Keywords

  • Diagnosis
  • Indeterminate colitis
  • Pediatric

ASJC Scopus subject areas

  • Immunology and Allergy
  • Gastroenterology

Fingerprint Dive into the research topics of 'Indeterminate colitis: A significant subgroup of pediatric IBD'. Together they form a unique fingerprint.

  • Cite this