Independent component analysis of SNPs reflects polygenic risk scores for schizophrenia

Jiayu Chen, Vince D. Calhoun, Godfrey D. Pearlson, Nora I. Perrone-Bizzozero, Jessica A. Turner, Stefan Ehrlich, Beng Choon Ho, Jingyu Liu

Research output: Contribution to journalArticlepeer-review

Abstract

Schizophrenia is a psychiatric disorder with high heritability. Recent genome-wide association studies have provided a list of risk loci reliably derived from unprecedentedly large samples. However, further delineation of the diagnosis-associated susceptibility variants is needed to better characterize the genetic architecture given the disease's complex nature. In this sense, a data-driven approach might hold promise for identifying functionally related clusters of genetic variants that might not be captured by hypothesis-based models. In the current study, independent component analysis (ICA) was applied to the Psychiatric Genomics Consortium's schizophrenia-related single nucleotide polymorphisms (SNPs) in 104 schizophrenia patients and 142 healthy controls of European Ancestry. We found that, for 13 out of 16 extracted independent components, the associated loadings correlated highly (r > 0.5) with the polygenic risk scores for SZ of the corresponding SNPs. These correlations were likely not inflated by the linkage disequilibrium structure (permutation p < 0.001). In brief, we demonstrate an example of ICA analysis on SNP data yielding functionally meaningful clusters, which motivates further application of data-driven approaches as a complimentary tool for hypothesis-based methods to enrich our knowledge on the genetic basis of complex disorders.

Original languageEnglish (US)
Pages (from-to)83-85
Number of pages3
JournalSchizophrenia Research
Volume181
DOIs
StatePublished - Mar 1 2017

Keywords

  • ICA
  • PGC
  • Polygenic risk score
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Fingerprint Dive into the research topics of 'Independent component analysis of SNPs reflects polygenic risk scores for schizophrenia'. Together they form a unique fingerprint.

Cite this