Independent comparison of CogState computerized testing and a standard cognitive battery with neuroimaging

Michelle M. Mielke, Stephen D. Weigand, Heather J. Wiste, Prashanthi Vemuri, Mary M. MacHulda, Davis S. Knopman, Val Lowe, Rosebud O. Roberts, Kejal Kantarci, Walter A. Rocca, Clifford R. Jack, Ronald C. Petersen

Research output: Contribution to journalArticle

Abstract

Background Inexpensive, non-invasive tools for assessing Alzheimer-type pathophysiologies are needed. Computerized cognitive assessments are prime candidates. Methods Cognitively normal participants, aged 51-71, with magnetic resonance imaging, fluorodeoxyglucose-positron emission tomography (FDG-PET), amyloid PET, CogState computerized cognitive assessment, and standard neuropsychological tests were included. We first examined the association between the CogState battery and neuroimaging measures. We then compared that association to the one between standard neuropsychological z-scores and neuroimaging. Results Slower reaction times for CogState Identification and One Back, and lower memory and attention z-scores, were associated (P

Original languageEnglish (US)
Pages (from-to)779-789
Number of pages11
JournalAlzheimer's and Dementia
Volume10
Issue number6
DOIs
StatePublished - Nov 1 2014
Externally publishedYes

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Neuroimaging
Neuropsychological Tests
Amyloid
Positron-Emission Tomography
Reaction Time
Magnetic Resonance Imaging

Keywords

  • Amyloidbeta
  • Computerized cognitive battery
  • Hippocampal volume
  • Neuroimaging
  • Neuropsychology
  • Preclinical Alzheimer's disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Developmental Neuroscience
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Epidemiology
  • Health Policy

Cite this

Mielke, M. M., Weigand, S. D., Wiste, H. J., Vemuri, P., MacHulda, M. M., Knopman, D. S., ... Petersen, R. C. (2014). Independent comparison of CogState computerized testing and a standard cognitive battery with neuroimaging. Alzheimer's and Dementia, 10(6), 779-789. https://doi.org/10.1016/j.jalz.2014.09.001

Independent comparison of CogState computerized testing and a standard cognitive battery with neuroimaging. / Mielke, Michelle M.; Weigand, Stephen D.; Wiste, Heather J.; Vemuri, Prashanthi; MacHulda, Mary M.; Knopman, Davis S.; Lowe, Val; Roberts, Rosebud O.; Kantarci, Kejal; Rocca, Walter A.; Jack, Clifford R.; Petersen, Ronald C.

In: Alzheimer's and Dementia, Vol. 10, No. 6, 01.11.2014, p. 779-789.

Research output: Contribution to journalArticle

Mielke, MM, Weigand, SD, Wiste, HJ, Vemuri, P, MacHulda, MM, Knopman, DS, Lowe, V, Roberts, RO, Kantarci, K, Rocca, WA, Jack, CR & Petersen, RC 2014, 'Independent comparison of CogState computerized testing and a standard cognitive battery with neuroimaging', Alzheimer's and Dementia, vol. 10, no. 6, pp. 779-789. https://doi.org/10.1016/j.jalz.2014.09.001
Mielke, Michelle M. ; Weigand, Stephen D. ; Wiste, Heather J. ; Vemuri, Prashanthi ; MacHulda, Mary M. ; Knopman, Davis S. ; Lowe, Val ; Roberts, Rosebud O. ; Kantarci, Kejal ; Rocca, Walter A. ; Jack, Clifford R. ; Petersen, Ronald C. / Independent comparison of CogState computerized testing and a standard cognitive battery with neuroimaging. In: Alzheimer's and Dementia. 2014 ; Vol. 10, No. 6. pp. 779-789.
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