TY - JOUR
T1 - Independence of changes in left ventricular diastolic properties of pericardial pressure
AU - Oldershaw, P. J.
AU - Shapiro, E.
AU - Mattheos, M.
AU - St John Sutton, M. G.
AU - Gibson, D.
PY - 1982
Y1 - 1982
N2 - There has been much interest in the published reports as to the extent to which measured left ventricular diastolic properties are affected by the pericardium. In this study observations were made on 24 patients, 7 days after cardiopulmonary bypass. Left ventricular dimensions were measured from echocardiographic recordings and left ventricular diastolic pressure assessed from measurements of isovolumic relaxation time. Pericardial pressure was measured directly using a small solid state transducer inserted into the pericardial space at the time of operation. Left ventricular diastolic properties were altered by either isometric handgrip or glyceryl trinitrate administration. Isometric handgrip produced an increase in cavity dimension at end-systole and diastole, with reduction in isovolumic relaxation time, suggesting an increase in left ventricular end-diastolic pressure; glyceryl trinitrate produced the reverse effect, with decreased cavity dimensions and prolongation of isovolumic relaxation time. These changes occurred in the absence of significant changes in pericardial pressure. The authors therefore conclude that even in the rather unusual conditions of the early postoperative period, when the sensitivity of pericardial pressure to small volume changes might be expected to be increased, substantial changes in left ventricular diastolic properties can occur without detectable alteration in pericardial pressure.
AB - There has been much interest in the published reports as to the extent to which measured left ventricular diastolic properties are affected by the pericardium. In this study observations were made on 24 patients, 7 days after cardiopulmonary bypass. Left ventricular dimensions were measured from echocardiographic recordings and left ventricular diastolic pressure assessed from measurements of isovolumic relaxation time. Pericardial pressure was measured directly using a small solid state transducer inserted into the pericardial space at the time of operation. Left ventricular diastolic properties were altered by either isometric handgrip or glyceryl trinitrate administration. Isometric handgrip produced an increase in cavity dimension at end-systole and diastole, with reduction in isovolumic relaxation time, suggesting an increase in left ventricular end-diastolic pressure; glyceryl trinitrate produced the reverse effect, with decreased cavity dimensions and prolongation of isovolumic relaxation time. These changes occurred in the absence of significant changes in pericardial pressure. The authors therefore conclude that even in the rather unusual conditions of the early postoperative period, when the sensitivity of pericardial pressure to small volume changes might be expected to be increased, substantial changes in left ventricular diastolic properties can occur without detectable alteration in pericardial pressure.
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U2 - 10.1136/hrt.48.2.125
DO - 10.1136/hrt.48.2.125
M3 - Article
C2 - 6807331
AN - SCOPUS:0019948993
VL - 48
SP - 125
EP - 129
JO - Advances in Water Resources
JF - Advances in Water Resources
SN - 0309-1708
IS - 2
ER -