Indefinite survival of MHC class I-deficient murine pancreatic islet allografts

James F. Markmann, Hamid Bassiri, Niraj M Desai, Jon S. Odorico, James I. Kim, Beverly H. Koller, Oliver Smithies, Clyde F. Barker

Research output: Contribution to journalArticle

Abstract

To examine the immune response to class I-deficient allogeneic tissue, we used β2-microglobulin-deficient mice as graft donors. These mice lack cell surface class I major histocompatibility complex antigen expression. Pancreatic islet allografts from class I-deficient donors survived indefinitely in a majority of fully allogeneic BALB/c recipients. In contrast, host recognition of graft class I antigen was unnecessary for prompt destruction of skin allografts of for autoimmune damage of transplanted pancreatic islet grafts in nonobese diabetic mice. These studies provide evidence that intentional genetic elimination of immunologically relevant donor antigens may prove an effective strategy for preventing allograft rejection.

Original languageEnglish (US)
Pages (from-to)1085-1089
Number of pages5
JournalTransplantation
Volume54
Issue number6
StatePublished - 1992
Externally publishedYes

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Islets of Langerhans
Allografts
Histocompatibility Antigens Class I
Transplants
Inbred NOD Mouse
Major Histocompatibility Complex
Antigens
Skin

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Markmann, J. F., Bassiri, H., Desai, N. M., Odorico, J. S., Kim, J. I., Koller, B. H., ... Barker, C. F. (1992). Indefinite survival of MHC class I-deficient murine pancreatic islet allografts. Transplantation, 54(6), 1085-1089.

Indefinite survival of MHC class I-deficient murine pancreatic islet allografts. / Markmann, James F.; Bassiri, Hamid; Desai, Niraj M; Odorico, Jon S.; Kim, James I.; Koller, Beverly H.; Smithies, Oliver; Barker, Clyde F.

In: Transplantation, Vol. 54, No. 6, 1992, p. 1085-1089.

Research output: Contribution to journalArticle

Markmann, JF, Bassiri, H, Desai, NM, Odorico, JS, Kim, JI, Koller, BH, Smithies, O & Barker, CF 1992, 'Indefinite survival of MHC class I-deficient murine pancreatic islet allografts', Transplantation, vol. 54, no. 6, pp. 1085-1089.
Markmann JF, Bassiri H, Desai NM, Odorico JS, Kim JI, Koller BH et al. Indefinite survival of MHC class I-deficient murine pancreatic islet allografts. Transplantation. 1992;54(6):1085-1089.
Markmann, James F. ; Bassiri, Hamid ; Desai, Niraj M ; Odorico, Jon S. ; Kim, James I. ; Koller, Beverly H. ; Smithies, Oliver ; Barker, Clyde F. / Indefinite survival of MHC class I-deficient murine pancreatic islet allografts. In: Transplantation. 1992 ; Vol. 54, No. 6. pp. 1085-1089.
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