Incremental prognostic value of post-stress left ventricular ejection fraction and volume by gated myocardial perfusion single photon emission computed tomography

Tali Sharir, Guido Germano, Paul B. Kavanagh, Shenghan Lai, Ishac Cohen, Howard C. Lewin, John D. Friedman, Michael J. Zellweger, Daniel S. Berman

Research output: Contribution to journalArticle

Abstract

Background - The incremental prognostic value of post-stress left ventricular ejection fraction (EF) and volume over perfusion has not been investigated. Methods and Results - We identified 1680 consecutive patients who underwent rest T1-201/stress Tc-99m sestamibi gated single photon emission computed tomography (SPECT) and who were followed-up for 569 ± days. Receiver-operator characteristics analysis defined an EF70 mL, and-an end-diastolic volume > 120 mL as optimal thresholds, yielding moderate sensitivity and high specificity in the prediction of cardiac death. Patients with an EF≥45% had mortality rates <1%/year, despite severe perfusion abnormalities, whereas patients with an EF70 mL and only mild/moderate perfusion abnormalities had high death rates (8.2%/year; P70 mL had high death rates (7.9%/year; P

Original languageEnglish (US)
Pages (from-to)1035-1042
Number of pages8
JournalCirculation
Volume100
Issue number10
StatePublished - Sep 7 1999
Externally publishedYes

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Single-Photon Emission-Computed Tomography
Stroke Volume
Perfusion
Mortality
Sensitivity and Specificity

Keywords

  • Cardiac volume
  • Imaging
  • Myocardial perfusion
  • Prognosis

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Incremental prognostic value of post-stress left ventricular ejection fraction and volume by gated myocardial perfusion single photon emission computed tomography. / Sharir, Tali; Germano, Guido; Kavanagh, Paul B.; Lai, Shenghan; Cohen, Ishac; Lewin, Howard C.; Friedman, John D.; Zellweger, Michael J.; Berman, Daniel S.

In: Circulation, Vol. 100, No. 10, 07.09.1999, p. 1035-1042.

Research output: Contribution to journalArticle

Sharir, T, Germano, G, Kavanagh, PB, Lai, S, Cohen, I, Lewin, HC, Friedman, JD, Zellweger, MJ & Berman, DS 1999, 'Incremental prognostic value of post-stress left ventricular ejection fraction and volume by gated myocardial perfusion single photon emission computed tomography', Circulation, vol. 100, no. 10, pp. 1035-1042.
Sharir, Tali ; Germano, Guido ; Kavanagh, Paul B. ; Lai, Shenghan ; Cohen, Ishac ; Lewin, Howard C. ; Friedman, John D. ; Zellweger, Michael J. ; Berman, Daniel S. / Incremental prognostic value of post-stress left ventricular ejection fraction and volume by gated myocardial perfusion single photon emission computed tomography. In: Circulation. 1999 ; Vol. 100, No. 10. pp. 1035-1042.
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AU - Germano, Guido

AU - Kavanagh, Paul B.

AU - Lai, Shenghan

AU - Cohen, Ishac

AU - Lewin, Howard C.

AU - Friedman, John D.

AU - Zellweger, Michael J.

AU - Berman, Daniel S.

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