Increasing usage of systemic antifungal agents

Thomas J. Walsh; Paul F. Jarosinski; Robert A. Fromtling

doi:10.1016/0732-8893(90)90051-V

Increasing usage of systemic antifungal agents

Thomas J. Walsh, Paul F. Jarosinski, Robert A. Fromtling

School of Medicine

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Original language	English (US)
Pages (from-to)	37-40
Number of pages	4
Journal	Diagnostic Microbiology and Infectious Disease
Volume	13
Issue number	1
DOIs	https://doi.org/10.1016/0732-8893(90)90051-V
State	Published - 1990

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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10.1016/0732-8893(90)90051-V

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@article{fd8ec3ffd5574f8bb86d6643dbcc5ec5,

title = "Increasing usage of systemic antifungal agents",

author = "Walsh, {Thomas J.} and Jarosinski, {Paul F.} and Fromtling, {Robert A.}",

note = "Funding Information: From the Infectious Diseases Section (T.J.W.), Pediatric Branch, National Cancer Institute; and Pharmacy Service (P.F.J.), National Institutes of Health, Bethesda, Maryland; and Department of Basic Microbiology (R.A.F.), Merck Institute for Therapeutic Research, Rahway, New Jersey. Address reprint requests to: Dr. T. J. Walsh, Infectious Diseases Section, National Cancer Institute, Building 10, Room 13N-240, Bethesda, MD 20892. Received September 14, 1989; revised and accepted October 17, 1989. {\textcopyright} 1990 Elsevier Science Publishing Co., Inc. 655 Avenue of the Americas, New York, NY 10010. 0732-8893/90/$3.50 Funding Information: from $34.6t o $64.8 million; and saleso f 5-FC in-creasedfr om$ 7.9t o $20.8m illion.T his trendi n the worldwideu seo f antifungadlr ugsis consistenwti th an increasinign cidenceo f fungali nfections. Uses of antifungadl rugsby countrya lso were consistenwti the merginpga tternisn theu seo f these therapeutaicg entsF. or examplei,n the UnitedS tates duringt he years1 983-1987k, etoconazolsea lesi n-creaseda t an annualr ateof 21c/~( annuals aleso f $10.7m illionin 1983t o $22.5m illionin 1987).F lu-cytosines alesi n the U.S.A. have dramaticalliyn - creaseda t an annualr ateof 38% (annuals aleso f $0.94m illioni n 1983t o$ 3.4m illioni n 1987)w, hereas amphotericBin u sed eclineds lightlyb y 6% annually in the samep eriod( annuasl aleso f $4.1m illionin 1983t o $3.2 million in 1987). In ordert o ascertainth ep atternos f usageo f an-tifungaal gentsin a largem edicarle ferracl enterw, e determinetdh e totaln umbero f units of amphotericin B, 5-FC, and ketoconazoluet, ilizedb y the Phar-macyS erviceo f the Clinical Centero f the National Instituteos f Health. Pharmacyre cordsw erecom-pletef or the years1 986t hrough1 988.I n addition, clotrimazolwe ass tudiedto determinteh et rendso f its usager elativeto systematicalalyd ministereadn - tifungacl ompounds. Usageo f amphotericiBn i ncreaseodv er6 0%f rom",

year = "1990",

doi = "10.1016/0732-8893(90)90051-V",

language = "English (US)",

volume = "13",

pages = "37--40",

journal = "Diagnostic Microbiology and Infectious Disease",

issn = "0732-8893",

publisher = "Elsevier Inc.",

number = "1",

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TY - JOUR

T1 - Increasing usage of systemic antifungal agents

AU - Walsh, Thomas J.

AU - Jarosinski, Paul F.

AU - Fromtling, Robert A.

N1 - Funding Information: From the Infectious Diseases Section (T.J.W.), Pediatric Branch, National Cancer Institute; and Pharmacy Service (P.F.J.), National Institutes of Health, Bethesda, Maryland; and Department of Basic Microbiology (R.A.F.), Merck Institute for Therapeutic Research, Rahway, New Jersey. Address reprint requests to: Dr. T. J. Walsh, Infectious Diseases Section, National Cancer Institute, Building 10, Room 13N-240, Bethesda, MD 20892. Received September 14, 1989; revised and accepted October 17, 1989. © 1990 Elsevier Science Publishing Co., Inc. 655 Avenue of the Americas, New York, NY 10010. 0732-8893/90/$3.50 Funding Information: from $34.6t o $64.8 million; and saleso f 5-FC in-creasedfr om$ 7.9t o $20.8m illion.T his trendi n the worldwideu seo f antifungadlr ugsis consistenwti th an increasinign cidenceo f fungali nfections. Uses of antifungadl rugsby countrya lso were consistenwti the merginpga tternisn theu seo f these therapeutaicg entsF. or examplei,n the UnitedS tates duringt he years1 983-1987k, etoconazolsea lesi n-creaseda t an annualr ateof 21c/~( annuals aleso f $10.7m illionin 1983t o $22.5m illionin 1987).F lu-cytosines alesi n the U.S.A. have dramaticalliyn - creaseda t an annualr ateof 38% (annuals aleso f $0.94m illioni n 1983t o$ 3.4m illioni n 1987)w, hereas amphotericBin u sed eclineds lightlyb y 6% annually in the samep eriod( annuasl aleso f $4.1m illionin 1983t o $3.2 million in 1987). In ordert o ascertainth ep atternos f usageo f an-tifungaal gentsin a largem edicarle ferracl enterw, e determinetdh e totaln umbero f units of amphotericin B, 5-FC, and ketoconazoluet, ilizedb y the Phar-macyS erviceo f the Clinical Centero f the National Instituteos f Health. Pharmacyre cordsw erecom-pletef or the years1 986t hrough1 988.I n addition, clotrimazolwe ass tudiedto determinteh et rendso f its usager elativeto systematicalalyd ministereadn - tifungacl ompounds. Usageo f amphotericiBn i ncreaseodv er6 0%f rom

PY - 1990

Y1 - 1990

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U2 - 10.1016/0732-8893(90)90051-V

DO - 10.1016/0732-8893(90)90051-V

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AN - SCOPUS:0025275328

SN - 0732-8893

VL - 13

SP - 37

EP - 40

JO - Diagnostic Microbiology and Infectious Disease

JF - Diagnostic Microbiology and Infectious Disease

IS - 1

ER -

Increasing usage of systemic antifungal agents

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