Increasing the signal-to-noise ratio in DENSE MRI by combining displacement-encoded echoes

Daniel Kim, Frederick H. Epstein, Wesley D. Gilson, Leon Axel

Research output: Contribution to journalArticle


A new technique was developed to increase the signal-to-noise ratio (SNR) in displacement encoding with stimulated echoes (DENSE) MRI. This signal-averaged DENSE (sav-DENSE) technique is based on the SNR advantage of extracting a pair of DENSE images with uncorrelated noise from the complex complementary spatial modulation of the magnetization image, and combining them during image reconstruction. Eleven healthy volunteers were imaged at three short-axis locations with the use of sav-DENSE, cine DENSE, and myocardial tagging pulse sequences. In this study, sav-DENSE increased the SNR by 15-34% as compared to cine DENSE. Circumferential strain values measured by sav-DENSE and myocardial tagging were strongly correlated (slope = 0.95, intercept = -0.02, R = 0.92) and within the 95% limits of agreement. The breath-hold sav-DENSE technique yielded relatively accurate and precise quantification of 2D intramyocardial function, with a 40.2-ms temporal resolution and a 3.5 × 3.5 mm2 spatial resolution.

Original languageEnglish (US)
Pages (from-to)188-192
Number of pages5
JournalMagnetic Resonance in Medicine
Issue number1
StatePublished - Jul 2004
Externally publishedYes



  • Heart
  • MRI
  • Myocardial strain
  • Wall motion

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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