Increasing the Donor Pool: Organ Transplantation from Donors with HIV to Recipients with HIV

Puja H. Nambiar, Brianna Doby, Aaron A.R. Tobian, Dorry L. Segev, Christine M. Durand

Research output: Contribution to journalReview articlepeer-review

Abstract

Implementation of the HIV Organ Policy Equity (HOPE) Act marks a new era in transplantation, allowing organ transplantation from HIV+ donors to HIV+ recipients (HIV D+/R+ transplantation). In this review, we discuss major milestones in HIV and transplantation which paved the way for this landmark policy change, including excellent outcomes in HIV D-/R+ recipient transplantation and success in the South African experience of HIV D+/R+ deceased donor kidney transplantation. Under the HOPE Act, from March 2016 to December 2018, there were 56 deceased donors, and 102 organs were transplanted (71 kidneys and 31 livers). In 2019, the first HIV D+/R+ living donor kidney transplants occurred. Reaching the full estimated potential of HIV+ donors will require overcoming challenges at the community, organ procurement organization, and transplant center levels. Multiple clinical trials are ongoing, which will provide clinical and scientific data to further extend the frontiers of knowledge in this field.

Original languageEnglish (US)
Pages (from-to)107-118
Number of pages12
JournalAnnual review of medicine
Volume72
DOIs
StatePublished - Jan 27 2021

Keywords

  • HIV Organ Policy Equity Act
  • HIV to HIV transplantation
  • HOPE Act
  • HOPE in Action
  • Solid organ transplantation
  • deceased donor transplantation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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