TY - JOUR
T1 - Increasing the Donor Pool
T2 - Organ Transplantation from Donors with HIV to Recipients with HIV
AU - Nambiar, Puja H.
AU - Doby, Brianna
AU - Tobian, Aaron A.R.
AU - Segev, Dorry L.
AU - Durand, Christine M.
N1 - Publisher Copyright:
© 2021 by Annual Reviews. All rights reserved.
PY - 2021/1/27
Y1 - 2021/1/27
N2 - Implementation of the HIV Organ Policy Equity (HOPE) Act marks a new era in transplantation, allowing organ transplantation from HIV+ donors to HIV+ recipients (HIV D+/R+ transplantation). In this review, we discuss major milestones in HIV and transplantation which paved the way for this landmark policy change, including excellent outcomes in HIV D-/R+ recipient transplantation and success in the South African experience of HIV D+/R+ deceased donor kidney transplantation. Under the HOPE Act, from March 2016 to December 2018, there were 56 deceased donors, and 102 organs were transplanted (71 kidneys and 31 livers). In 2019, the first HIV D+/R+ living donor kidney transplants occurred. Reaching the full estimated potential of HIV+ donors will require overcoming challenges at the community, organ procurement organization, and transplant center levels. Multiple clinical trials are ongoing, which will provide clinical and scientific data to further extend the frontiers of knowledge in this field.
AB - Implementation of the HIV Organ Policy Equity (HOPE) Act marks a new era in transplantation, allowing organ transplantation from HIV+ donors to HIV+ recipients (HIV D+/R+ transplantation). In this review, we discuss major milestones in HIV and transplantation which paved the way for this landmark policy change, including excellent outcomes in HIV D-/R+ recipient transplantation and success in the South African experience of HIV D+/R+ deceased donor kidney transplantation. Under the HOPE Act, from March 2016 to December 2018, there were 56 deceased donors, and 102 organs were transplanted (71 kidneys and 31 livers). In 2019, the first HIV D+/R+ living donor kidney transplants occurred. Reaching the full estimated potential of HIV+ donors will require overcoming challenges at the community, organ procurement organization, and transplant center levels. Multiple clinical trials are ongoing, which will provide clinical and scientific data to further extend the frontiers of knowledge in this field.
KW - HIV Organ Policy Equity Act
KW - HIV to HIV transplantation
KW - HOPE Act
KW - HOPE in Action
KW - Solid organ transplantation
KW - deceased donor transplantation
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UR - http://www.scopus.com/inward/citedby.url?scp=85100195736&partnerID=8YFLogxK
U2 - 10.1146/annurev-med-060419-122327
DO - 10.1146/annurev-med-060419-122327
M3 - Review article
C2 - 33502896
AN - SCOPUS:85100195736
SN - 0066-4219
VL - 72
SP - 107
EP - 118
JO - Annual review of medicine
JF - Annual review of medicine
ER -