Increasing pneumococcal vaccination for immunosuppressed patients

A cluster quality improvement trial

Sonali P. Desai, Bing Lu, Lara E. Szent-Gyorgyi, Anna A. Bogdanova, Alexander Turchin, Michael Weinblatt, Jonathan Coblyn, Jeffrey O. Greenberg, Allen Kachalia, Daniel H. Solomon

Research output: Contribution to journalArticle

Abstract

Objective Pneumococcal vaccination is important for patients taking immunosuppressive medications, but prior studies suggest that most patients do not undergo vaccination. The aim of this study was to evaluate the effects of a point-of-care paper reminder form as a quality improvement (QI) strategy to increase the numbers of immunosuppressed patients being kept up-to-date with pneumococcal vaccination in a rheumatology practice. Methods Selected rheumatologists at 5 ambulatory practice sites received a point-of-care paper reminder form to be applied to patients who were not up-to-date with pneumococcal vaccination. Interrupted time-series analyses were used to measure the effect of the intervention on the pneumococcal vaccination rates among patients, comparing the rates in the intervention group with those in a control group of rheumatologists who did not receive the intervention. Adjusted Cox proportional hazards models were examined to identify independent predictors of being up-to-date with pneumococcal vaccination. Results We evaluated a total of 3,717 patients (66.0% with rheumatoid arthritis) who were taking immunosuppressive medications (74.1% women, mean age 53.7 years). Rheumatologists who received the intervention had a significant increase in the rate of patients who were up-to-date with pneumococcal vaccination, from 67.6% to 80.0% (P = 0.006), in the time period following the intervention, compared to a rate that remained stable, from 52.3% to 52.0% (P = 0.90), among patients in the nonintervention control group during this same time period. In regression models, positive predictors of being up-to-date with pneumococcal vaccination at the patient level included the following: having received the intervention (hazard ratio [HR] 3.58, 95% confidence interval [95% CI] 2.46-5.20), having a primary care physician affiliated with Brigham and Women's Hospital (HR 1.68, 95% CI 1.44-1.97), having a diagnosis of diabetes mellitus (HR 1.57, 95% CI 1.02-2.41), and being age 56-65 years at baseline, compared to age ≤45 years (HR 1.24, 95% CI 1.01-1.51). Conclusion A QI strategy involving a simple point-of-care paper reminder form significantly increased the rate of being up-to-date with pneumococcal vaccination among patients receiving immunosuppressive medications in our rheumatology practices over a 6-month period.

Original languageEnglish (US)
Pages (from-to)39-47
Number of pages9
JournalArthritis and rheumatism
Volume65
Issue number1
DOIs
StatePublished - Jan 1 2013
Externally publishedYes

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Quality Improvement
Vaccination
Point-of-Care Systems
Immunosuppressive Agents
Confidence Intervals
Rheumatology
Control Groups
Primary Care Physicians
Proportional Hazards Models
Rheumatoid Arthritis
Diabetes Mellitus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

Cite this

Desai, S. P., Lu, B., Szent-Gyorgyi, L. E., Bogdanova, A. A., Turchin, A., Weinblatt, M., ... Solomon, D. H. (2013). Increasing pneumococcal vaccination for immunosuppressed patients: A cluster quality improvement trial. Arthritis and rheumatism, 65(1), 39-47. https://doi.org/10.1002/art.37716

Increasing pneumococcal vaccination for immunosuppressed patients : A cluster quality improvement trial. / Desai, Sonali P.; Lu, Bing; Szent-Gyorgyi, Lara E.; Bogdanova, Anna A.; Turchin, Alexander; Weinblatt, Michael; Coblyn, Jonathan; Greenberg, Jeffrey O.; Kachalia, Allen; Solomon, Daniel H.

In: Arthritis and rheumatism, Vol. 65, No. 1, 01.01.2013, p. 39-47.

Research output: Contribution to journalArticle

Desai, SP, Lu, B, Szent-Gyorgyi, LE, Bogdanova, AA, Turchin, A, Weinblatt, M, Coblyn, J, Greenberg, JO, Kachalia, A & Solomon, DH 2013, 'Increasing pneumococcal vaccination for immunosuppressed patients: A cluster quality improvement trial', Arthritis and rheumatism, vol. 65, no. 1, pp. 39-47. https://doi.org/10.1002/art.37716
Desai SP, Lu B, Szent-Gyorgyi LE, Bogdanova AA, Turchin A, Weinblatt M et al. Increasing pneumococcal vaccination for immunosuppressed patients: A cluster quality improvement trial. Arthritis and rheumatism. 2013 Jan 1;65(1):39-47. https://doi.org/10.1002/art.37716
Desai, Sonali P. ; Lu, Bing ; Szent-Gyorgyi, Lara E. ; Bogdanova, Anna A. ; Turchin, Alexander ; Weinblatt, Michael ; Coblyn, Jonathan ; Greenberg, Jeffrey O. ; Kachalia, Allen ; Solomon, Daniel H. / Increasing pneumococcal vaccination for immunosuppressed patients : A cluster quality improvement trial. In: Arthritis and rheumatism. 2013 ; Vol. 65, No. 1. pp. 39-47.
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abstract = "Objective Pneumococcal vaccination is important for patients taking immunosuppressive medications, but prior studies suggest that most patients do not undergo vaccination. The aim of this study was to evaluate the effects of a point-of-care paper reminder form as a quality improvement (QI) strategy to increase the numbers of immunosuppressed patients being kept up-to-date with pneumococcal vaccination in a rheumatology practice. Methods Selected rheumatologists at 5 ambulatory practice sites received a point-of-care paper reminder form to be applied to patients who were not up-to-date with pneumococcal vaccination. Interrupted time-series analyses were used to measure the effect of the intervention on the pneumococcal vaccination rates among patients, comparing the rates in the intervention group with those in a control group of rheumatologists who did not receive the intervention. Adjusted Cox proportional hazards models were examined to identify independent predictors of being up-to-date with pneumococcal vaccination. Results We evaluated a total of 3,717 patients (66.0{\%} with rheumatoid arthritis) who were taking immunosuppressive medications (74.1{\%} women, mean age 53.7 years). Rheumatologists who received the intervention had a significant increase in the rate of patients who were up-to-date with pneumococcal vaccination, from 67.6{\%} to 80.0{\%} (P = 0.006), in the time period following the intervention, compared to a rate that remained stable, from 52.3{\%} to 52.0{\%} (P = 0.90), among patients in the nonintervention control group during this same time period. In regression models, positive predictors of being up-to-date with pneumococcal vaccination at the patient level included the following: having received the intervention (hazard ratio [HR] 3.58, 95{\%} confidence interval [95{\%} CI] 2.46-5.20), having a primary care physician affiliated with Brigham and Women's Hospital (HR 1.68, 95{\%} CI 1.44-1.97), having a diagnosis of diabetes mellitus (HR 1.57, 95{\%} CI 1.02-2.41), and being age 56-65 years at baseline, compared to age ≤45 years (HR 1.24, 95{\%} CI 1.01-1.51). Conclusion A QI strategy involving a simple point-of-care paper reminder form significantly increased the rate of being up-to-date with pneumococcal vaccination among patients receiving immunosuppressive medications in our rheumatology practices over a 6-month period.",
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T2 - A cluster quality improvement trial

AU - Desai, Sonali P.

AU - Lu, Bing

AU - Szent-Gyorgyi, Lara E.

AU - Bogdanova, Anna A.

AU - Turchin, Alexander

AU - Weinblatt, Michael

AU - Coblyn, Jonathan

AU - Greenberg, Jeffrey O.

AU - Kachalia, Allen

AU - Solomon, Daniel H.

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N2 - Objective Pneumococcal vaccination is important for patients taking immunosuppressive medications, but prior studies suggest that most patients do not undergo vaccination. The aim of this study was to evaluate the effects of a point-of-care paper reminder form as a quality improvement (QI) strategy to increase the numbers of immunosuppressed patients being kept up-to-date with pneumococcal vaccination in a rheumatology practice. Methods Selected rheumatologists at 5 ambulatory practice sites received a point-of-care paper reminder form to be applied to patients who were not up-to-date with pneumococcal vaccination. Interrupted time-series analyses were used to measure the effect of the intervention on the pneumococcal vaccination rates among patients, comparing the rates in the intervention group with those in a control group of rheumatologists who did not receive the intervention. Adjusted Cox proportional hazards models were examined to identify independent predictors of being up-to-date with pneumococcal vaccination. Results We evaluated a total of 3,717 patients (66.0% with rheumatoid arthritis) who were taking immunosuppressive medications (74.1% women, mean age 53.7 years). Rheumatologists who received the intervention had a significant increase in the rate of patients who were up-to-date with pneumococcal vaccination, from 67.6% to 80.0% (P = 0.006), in the time period following the intervention, compared to a rate that remained stable, from 52.3% to 52.0% (P = 0.90), among patients in the nonintervention control group during this same time period. In regression models, positive predictors of being up-to-date with pneumococcal vaccination at the patient level included the following: having received the intervention (hazard ratio [HR] 3.58, 95% confidence interval [95% CI] 2.46-5.20), having a primary care physician affiliated with Brigham and Women's Hospital (HR 1.68, 95% CI 1.44-1.97), having a diagnosis of diabetes mellitus (HR 1.57, 95% CI 1.02-2.41), and being age 56-65 years at baseline, compared to age ≤45 years (HR 1.24, 95% CI 1.01-1.51). Conclusion A QI strategy involving a simple point-of-care paper reminder form significantly increased the rate of being up-to-date with pneumococcal vaccination among patients receiving immunosuppressive medications in our rheumatology practices over a 6-month period.

AB - Objective Pneumococcal vaccination is important for patients taking immunosuppressive medications, but prior studies suggest that most patients do not undergo vaccination. The aim of this study was to evaluate the effects of a point-of-care paper reminder form as a quality improvement (QI) strategy to increase the numbers of immunosuppressed patients being kept up-to-date with pneumococcal vaccination in a rheumatology practice. Methods Selected rheumatologists at 5 ambulatory practice sites received a point-of-care paper reminder form to be applied to patients who were not up-to-date with pneumococcal vaccination. Interrupted time-series analyses were used to measure the effect of the intervention on the pneumococcal vaccination rates among patients, comparing the rates in the intervention group with those in a control group of rheumatologists who did not receive the intervention. Adjusted Cox proportional hazards models were examined to identify independent predictors of being up-to-date with pneumococcal vaccination. Results We evaluated a total of 3,717 patients (66.0% with rheumatoid arthritis) who were taking immunosuppressive medications (74.1% women, mean age 53.7 years). Rheumatologists who received the intervention had a significant increase in the rate of patients who were up-to-date with pneumococcal vaccination, from 67.6% to 80.0% (P = 0.006), in the time period following the intervention, compared to a rate that remained stable, from 52.3% to 52.0% (P = 0.90), among patients in the nonintervention control group during this same time period. In regression models, positive predictors of being up-to-date with pneumococcal vaccination at the patient level included the following: having received the intervention (hazard ratio [HR] 3.58, 95% confidence interval [95% CI] 2.46-5.20), having a primary care physician affiliated with Brigham and Women's Hospital (HR 1.68, 95% CI 1.44-1.97), having a diagnosis of diabetes mellitus (HR 1.57, 95% CI 1.02-2.41), and being age 56-65 years at baseline, compared to age ≤45 years (HR 1.24, 95% CI 1.01-1.51). Conclusion A QI strategy involving a simple point-of-care paper reminder form significantly increased the rate of being up-to-date with pneumococcal vaccination among patients receiving immunosuppressive medications in our rheumatology practices over a 6-month period.

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