Increasing levels of pretreatment HIV drug resistance and safety concerns for dolutegravir use in women of reproductive age

Seth Chekata Inzaule; Michael R. Jordan; Amandine Cournil; Marco Vitoria; Giovanni Ravasi; Fatim Cham; Linh Vi Le; Janet Dzangare; Ndapewa Hamunime; Nicholus Mutenda; Avelin Aghokeng; Annez Bissek; Serge Billong; Pontiano Kaleebu; Meg Doherty; Silvia Bertagnolio

doi:10.1097/QAD.0000000000002277

Increasing levels of pretreatment HIV drug resistance and safety concerns for dolutegravir use in women of reproductive age

Seth Chekata Inzaule, Michael R. Jordan, Amandine Cournil, Marco Vitoria, Giovanni Ravasi, Fatim Cham, Linh Vi Le, Janet Dzangare, Ndapewa Hamunime, Nicholus Mutenda, Avelin Aghokeng, Annez Bissek, Serge Billong, Pontiano Kaleebu, Meg Doherty, Silvia Bertagnolio

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Use of dolutegravir-based first-line antiretroviral therapy (ART) in response to rising levels of pretreatment HIV drug resistance (PDR) to non-nucleoside reverse transcriptase inhibitors (NNRTIs) may be limited, given safety concerns for birth defects in women of child-bearing potential. Pooled data from 11 nationally representative surveys show that NNRTI PDR in women is nearly twice that in men, exceeding 10% in 8 of 11 countries monitored, suggesting the urgent need for a non-NNRTI-based ART regimen in this population.

Original language	English (US)
Pages (from-to)	1797-1799
Number of pages	3
Journal	AIDS
Volume	33
Issue number	11
DOIs	https://doi.org/10.1097/QAD.0000000000002277
State	Published - Sep 1 2019

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

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10.1097/QAD.0000000000002277

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Inzaule, S. C., Jordan, M. R., Cournil, A., Vitoria, M., Ravasi, G., Cham, F., Le, L. V., Dzangare, J., Hamunime, N., Mutenda, N., Aghokeng, A., Bissek, A., Billong, S., Kaleebu, P., Doherty, M., & Bertagnolio, S. (2019). Increasing levels of pretreatment HIV drug resistance and safety concerns for dolutegravir use in women of reproductive age. AIDS, 33(11), 1797-1799. https://doi.org/10.1097/QAD.0000000000002277

Increasing levels of pretreatment HIV drug resistance and safety concerns for dolutegravir use in women of reproductive age. / Inzaule, Seth Chekata; Jordan, Michael R.; Cournil, Amandine; Vitoria, Marco; Ravasi, Giovanni; Cham, Fatim; Le, Linh Vi; Dzangare, Janet; Hamunime, Ndapewa; Mutenda, Nicholus; Aghokeng, Avelin; Bissek, Annez; Billong, Serge; Kaleebu, Pontiano; Doherty, Meg; Bertagnolio, Silvia.

In: AIDS, Vol. 33, No. 11, 01.09.2019, p. 1797-1799.

Research output: Contribution to journal › Article › peer-review

Inzaule, SC, Jordan, MR, Cournil, A, Vitoria, M, Ravasi, G, Cham, F, Le, LV, Dzangare, J, Hamunime, N, Mutenda, N, Aghokeng, A, Bissek, A, Billong, S, Kaleebu, P, Doherty, M & Bertagnolio, S 2019, 'Increasing levels of pretreatment HIV drug resistance and safety concerns for dolutegravir use in women of reproductive age', AIDS, vol. 33, no. 11, pp. 1797-1799. https://doi.org/10.1097/QAD.0000000000002277

Inzaule, Seth Chekata ; Jordan, Michael R. ; Cournil, Amandine ; Vitoria, Marco ; Ravasi, Giovanni ; Cham, Fatim ; Le, Linh Vi ; Dzangare, Janet ; Hamunime, Ndapewa ; Mutenda, Nicholus ; Aghokeng, Avelin ; Bissek, Annez ; Billong, Serge ; Kaleebu, Pontiano ; Doherty, Meg ; Bertagnolio, Silvia. / Increasing levels of pretreatment HIV drug resistance and safety concerns for dolutegravir use in women of reproductive age. In: AIDS. 2019 ; Vol. 33, No. 11. pp. 1797-1799.

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abstract = "Use of dolutegravir-based first-line antiretroviral therapy (ART) in response to rising levels of pretreatment HIV drug resistance (PDR) to non-nucleoside reverse transcriptase inhibitors (NNRTIs) may be limited, given safety concerns for birth defects in women of child-bearing potential. Pooled data from 11 nationally representative surveys show that NNRTI PDR in women is nearly twice that in men, exceeding 10% in 8 of 11 countries monitored, suggesting the urgent need for a non-NNRTI-based ART regimen in this population.",

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Increasing levels of pretreatment HIV drug resistance and safety concerns for dolutegravir use in women of reproductive age

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