Increasing Clindamycin and Trimethoprim-Sulfamethoxazole Resistance in Pediatric Staphylococcus aureus Infections

Dina F. Khamash; Annie Voskertchian; Pranita D. Tamma; Ibukunoluwa C. Akinboyo; Karen C. Carroll; Aaron M. Milstone

doi:10.1093/jpids/piy062

Increasing Clindamycin and Trimethoprim-Sulfamethoxazole Resistance in Pediatric Staphylococcus aureus Infections

Dina F. Khamash, Annie Voskertchian, Pranita D. Tamma, Ibukunoluwa C. Akinboyo, Karen C. Carroll, Aaron M. Milstone

School of Medicine

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

The epidemiology of Staphylococcus aureus infection in children is dynamic. We conducted a retrospective observational study on pediatric clinical cultures, performed between 2005 and 2017, that grew S aureus to determine temporal trends in antibiotic resistance. Although methicillin resistance declined, clindamycin and trimethoprim-sulfamethoxazole resistance increased significantly, especially among community-onset isolates.

Original language	English (US)
Pages (from-to)	351-353
Number of pages	3
Journal	Journal of the Pediatric Infectious Diseases Society
Volume	8
Issue number	4
DOIs	https://doi.org/10.1093/jpids/piy062
State	Published - Jan 18 2019

Keywords

Staphylococcus aureus
antibiotic resistance
clindamycin
community-onset infection
pediatrics
trimethoprim-sulfamethoxazole

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Infectious Diseases

Access to Document

10.1093/jpids/piy062

Cite this

@article{93f9b1b5370a4bcfa1562f855bd7db73,

title = "Increasing Clindamycin and Trimethoprim-Sulfamethoxazole Resistance in Pediatric Staphylococcus aureus Infections",

abstract = "The epidemiology of Staphylococcus aureus infection in children is dynamic. We conducted a retrospective observational study on pediatric clinical cultures, performed between 2005 and 2017, that grew S aureus to determine temporal trends in antibiotic resistance. Although methicillin resistance declined, clindamycin and trimethoprim-sulfamethoxazole resistance increased significantly, especially among community-onset isolates.",

keywords = "Staphylococcus aureus, antibiotic resistance, clindamycin, community-onset infection, pediatrics, trimethoprim-sulfamethoxazole",

author = "Khamash, {Dina F.} and Annie Voskertchian and Tamma, {Pranita D.} and Akinboyo, {Ibukunoluwa C.} and Carroll, {Karen C.} and Milstone, {Aaron M.}",

note = "Funding Information: Financial support. This work was supported in part by the Agency for Healthcare Research and Quality (grant R01HS022872). Publisher Copyright: {\textcopyright} 2018 The Author(s) 2018. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. All rights reserved.",

year = "2019",

month = jan,

day = "18",

doi = "10.1093/jpids/piy062",

language = "English (US)",

volume = "8",

pages = "351--353",

journal = "Journal of the Pediatric Infectious Diseases Society",

issn = "2048-7193",

publisher = "Oxford University Press",

number = "4",

}

TY - JOUR

T1 - Increasing Clindamycin and Trimethoprim-Sulfamethoxazole Resistance in Pediatric Staphylococcus aureus Infections

AU - Khamash, Dina F.

AU - Voskertchian, Annie

AU - Tamma, Pranita D.

AU - Akinboyo, Ibukunoluwa C.

AU - Carroll, Karen C.

AU - Milstone, Aaron M.

N1 - Funding Information: Financial support. This work was supported in part by the Agency for Healthcare Research and Quality (grant R01HS022872). Publisher Copyright: © 2018 The Author(s) 2018. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. All rights reserved.

PY - 2019/1/18

Y1 - 2019/1/18

N2 - The epidemiology of Staphylococcus aureus infection in children is dynamic. We conducted a retrospective observational study on pediatric clinical cultures, performed between 2005 and 2017, that grew S aureus to determine temporal trends in antibiotic resistance. Although methicillin resistance declined, clindamycin and trimethoprim-sulfamethoxazole resistance increased significantly, especially among community-onset isolates.

AB - The epidemiology of Staphylococcus aureus infection in children is dynamic. We conducted a retrospective observational study on pediatric clinical cultures, performed between 2005 and 2017, that grew S aureus to determine temporal trends in antibiotic resistance. Although methicillin resistance declined, clindamycin and trimethoprim-sulfamethoxazole resistance increased significantly, especially among community-onset isolates.

KW - Staphylococcus aureus

KW - antibiotic resistance

KW - clindamycin

KW - community-onset infection

KW - pediatrics

KW - trimethoprim-sulfamethoxazole

UR - http://www.scopus.com/inward/record.url?scp=85072685964&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85072685964&partnerID=8YFLogxK

U2 - 10.1093/jpids/piy062

DO - 10.1093/jpids/piy062

M3 - Article

C2 - 30011009

AN - SCOPUS:85072685964

SN - 2048-7193

VL - 8

SP - 351

EP - 353

JO - Journal of the Pediatric Infectious Diseases Society

JF - Journal of the Pediatric Infectious Diseases Society

IS - 4

ER -

Increasing Clindamycin and Trimethoprim-Sulfamethoxazole Resistance in Pediatric Staphylococcus aureus Infections

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this