TY - JOUR
T1 - Increased vertical transmission of human immunodeficiency virus from hepatitis C virus-coinfected mothers
AU - Hershow, Ronald C.
AU - Riester, Katherine A.
AU - Lew, Judy
AU - Quinn, Thomas C
AU - Mofenson, Lynne M.
AU - Davenny, Katherine
AU - Landesman, Sheldon
AU - Cotton, Deborah
AU - Celine Hanson, I.
AU - Hillyer, George V.
AU - Tang, Hope Babette
AU - Thomas, David L.
N1 - Funding Information:
Population and study design. WITS is an ongoing, prospective, multicenter study of the natural history of HIV-infected pregnant women and their infants, jointly sponsored by the National Institute of Allergy and Infectious Diseases, the National Institute of Child Health and Human Development, and the National Institute of Drug Abuse (NIH). The study is conducted in pediatric and obstetric clinics in medical centers in Chicago (Illinois), New York City and Brooklyn (New York), San Juan (Puerto Rico), the Boston-Worcester area (Massachusetts), and Houston (Texas).
PY - 1997
Y1 - 1997
N2 - To determine if hepatitis C virus (HCV) infection affects vertical transmission of human immunodeficiency virus (HIV), 487 HIV-infected pregnant women in the prospective, multicenter, Women and Infants Transmission Study had HCV antibody (anti-HCV by second-generation ELISA) and HCV RNA (by quantitative polymerase chain reaction) measured in peripartum maternal plasma; 161 (33%) were anti-HCV-positive. HIV vertical transmission occurred from 42 HCV-infected mothers (26.1%) versus 53 HCV-uninfected mothers (16.3%; odds radio [OR], 1.82; P = .01). In a logistic regression model that included maternal drug use, a potential confounder, HCV infection was marginally associated with perinatal HIV transmission (OR, 1.64; P = .05), whereas drug use was not. Women who transmitted HIV had higher levels of HCV RNA (median, 721,254 copies/mL) than those who did not (337,561 copies/mL; P = .01). Maternal HCV infection is associated with increased HIV vertical transmission. Further studies are needed to ascertain if HCV directly affects perinatal HIV transmission or is a marker for another factor, such as maternal drug use.
AB - To determine if hepatitis C virus (HCV) infection affects vertical transmission of human immunodeficiency virus (HIV), 487 HIV-infected pregnant women in the prospective, multicenter, Women and Infants Transmission Study had HCV antibody (anti-HCV by second-generation ELISA) and HCV RNA (by quantitative polymerase chain reaction) measured in peripartum maternal plasma; 161 (33%) were anti-HCV-positive. HIV vertical transmission occurred from 42 HCV-infected mothers (26.1%) versus 53 HCV-uninfected mothers (16.3%; odds radio [OR], 1.82; P = .01). In a logistic regression model that included maternal drug use, a potential confounder, HCV infection was marginally associated with perinatal HIV transmission (OR, 1.64; P = .05), whereas drug use was not. Women who transmitted HIV had higher levels of HCV RNA (median, 721,254 copies/mL) than those who did not (337,561 copies/mL; P = .01). Maternal HCV infection is associated with increased HIV vertical transmission. Further studies are needed to ascertain if HCV directly affects perinatal HIV transmission or is a marker for another factor, such as maternal drug use.
UR - http://www.scopus.com/inward/record.url?scp=16944364046&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=16944364046&partnerID=8YFLogxK
U2 - 10.1086/514058
DO - 10.1086/514058
M3 - Article
C2 - 9237706
AN - SCOPUS:16944364046
SN - 0022-1899
VL - 176
SP - 414
EP - 420
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 2
ER -