Increased vasopressin secretion and release in mice transgenic for the rat arginine vasopressin gene

Myron Miller, Shigeki Kawabata, Michelle Wiltshire-Clement, Jaume Reventos, Jon W. Gordon

Research output: Contribution to journalArticle

Abstract

The rat arginine vasopressin (AVP) genomic sequence has been utilized to develop a line of transgenic mice homozygous and heterozygous for the transgene. Expression of the rat AVP gene was demonstrated by Southern blotting and resulted in increased amounts of AVP in hypothalamus and frontotempo- ral brain cortex. Secretion of AVP from the neurohypophysial system results in an increased concentration of the hormone in the plasma and in an increased excretion in the urine in amounts three to five times those of normal mice. Extraneural ectopic hormone production was found only in the pancreas. Despite chronic hypersecretion of AVP, 24-hour urine volume and osmolality did not show evidence of increased antidiuretic hormone action on the kidney, so that, under basal conditions, the water balance in the animals is unaffected.

Original languageEnglish (US)
Pages (from-to)621-625
Number of pages5
JournalNeuroendocrinology
Volume57
Issue number4
DOIs
StatePublished - Jan 1 1993
Externally publishedYes

Keywords

  • Arginine vasopressin
  • Neurohypophysial system
  • Transgenic mice
  • Vasopressin
  • Water regulation

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

Fingerprint Dive into the research topics of 'Increased vasopressin secretion and release in mice transgenic for the rat arginine vasopressin gene'. Together they form a unique fingerprint.

  • Cite this