Increased urinary excretion of lipids by patients with kidney stones

S. R. Khan, P. A. Glenton

Research output: Contribution to journalArticlepeer-review

Abstract

Objective. To test the hypothesis that patients with calcific kidney stones (stone formers) excrete more lipids and cell membranes in their urine than do normal individuals. Patients, subjects and methods. Lipids were isolated from the urine of patients with calcific stones (four women and six men, age range 28-69 years) and from normal subjects (three men and three women, age range 31-54 years). Different phospholipids, neutral lipids and glycolipids were identified using thin layer chromatography and individual lipids were characterized by several assays after scraping the spots from the plates, or by densitometry. Results. Stone formers excreted more lipids and acidic phospholipids than did normal individuals; the urinary excretion of glycolipid, cholesterol and cholesterol esters was also increased. Conclusions. The greater excretion of lipids may reflect the increased turnover of cells in the tubular epithelium and sloughing of cells into the urine in response to a challenge by oxalate and calcium oxalate crystals. Acidic phospholipids from cellular membranes of the sloughed epithelial cells may be involved in crystal nucleation and retention within the kidneys and thus the initial development of stone nidus and the continued growth thereafter.

Original languageEnglish (US)
Pages (from-to)506-511
Number of pages6
JournalBritish Journal of Urology
Volume77
Issue number4
StatePublished - 1996
Externally publishedYes

Keywords

  • Biomineralization
  • Calcification
  • Calcium oxalate
  • Nephrolithiasis
  • Phospholipids

ASJC Scopus subject areas

  • Urology

Fingerprint Dive into the research topics of 'Increased urinary excretion of lipids by patients with kidney stones'. Together they form a unique fingerprint.

Cite this