Increased temporal lobe glucose use in chronic schizophrenic patients

Lynn E. DeLisi, Monte S. Buchsbaum, Henry H. Holcomb, Katharine C. Langston, A. Catherine King, Robert Kessler, David Pickar, William T. Carpenter, John M. Morihisa, Richard Margolin, Daniel R. Weinberger

Research output: Contribution to journalArticle

Abstract

Temporal lobe glucose metabolic rate was assessed in 21 off-medication patients with schizophrenia and 19 normal controls by positron emission tomography with 18F-deoxyglucose. Patients with schizophrenia had significantly greater metabolic activity in the left than the right anterior temporal lobe, and the extent of this lateralization was in proportion to the severity of psychopathology.

Original languageEnglish (US)
Pages (from-to)835-851
Number of pages17
JournalBiological psychiatry
Volume25
Issue number7
DOIs
StatePublished - Apr 1 1989

ASJC Scopus subject areas

  • Biological Psychiatry

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    DeLisi, L. E., S. Buchsbaum, M., Holcomb, H. H., Langston, K. C., King, A. C., Kessler, R., Pickar, D., Carpenter, W. T., Morihisa, J. M., Margolin, R., & Weinberger, D. R. (1989). Increased temporal lobe glucose use in chronic schizophrenic patients. Biological psychiatry, 25(7), 835-851. https://doi.org/10.1016/0006-3223(89)90263-1