Increased systolic performance with diastolic dysfunction in adult spontaneously hypertensive rats

Oscar Cingolani, Xiao Ping Yang, Maria A. Cavasin, Oscar A. Carretero

Research output: Contribution to journalArticle

Abstract

Hypertensive heart disease is characterized by early development of hypertrophy and fibrosis that leads to heart failure (HF). HF develops in spontaneously hypertensive rats (SHR) after 18 months; however, it is not clear whether hypertrophy leads to altered cardiac performance at an earlier age in these rats. We studied cardiac performance in 10- to 11-month-old SHR and age-matched Wistar-Kyoto rats (WKY), using presssure-volume (PV) conductance catheter system to evaluate systolic and diastolic function in vivo at different preloads, including preload recruitable stroke work (PRSW), +dP/dt, and its relation to end-diastolic volume (+dP/dt-EDV) and preload-adjusted maximal power (PWRmax-EDV2) as well as the time constant of left ventricular pressure decay, tau (τ), as an index of relaxation. The slope of the end-diastolic pressure-volume relation (EDPVR) and the ex vivo PV relation, both indexes of stiffness, were also calculated for each heart, and the Doppler E/A ratio was determined. In addition, plasma samples were obtained to assess B-type natriuretic peptide levels (BNP). We found that PRSW was higher in SHR than in WKY (174.5±15.6 versus 92.6±18.9 mm Hg; P2 was elevated in SHR (7.3±1.5 versus 3.1±0.6 mW/μL2). τ was prolonged in SHR (14.5±1 ms versus 10.8±0.8 for WKY, P

Original languageEnglish (US)
Pages (from-to)249-254
Number of pages6
JournalHypertension
Volume41
Issue number2
DOIs
StatePublished - Feb 1 2003
Externally publishedYes

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Inbred SHR Rats
Inbred WKY Rats
Hypertrophy
Heart Failure
Stroke
Brain Natriuretic Peptide
Ventricular Pressure
Heart Diseases
Fibrosis
Catheters
Blood Pressure

Keywords

  • Diastole
  • Fibrosis
  • Hypertrophy
  • Rats, spontaneously hypertensive
  • Systole

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Increased systolic performance with diastolic dysfunction in adult spontaneously hypertensive rats. / Cingolani, Oscar; Yang, Xiao Ping; Cavasin, Maria A.; Carretero, Oscar A.

In: Hypertension, Vol. 41, No. 2, 01.02.2003, p. 249-254.

Research output: Contribution to journalArticle

Cingolani, Oscar ; Yang, Xiao Ping ; Cavasin, Maria A. ; Carretero, Oscar A. / Increased systolic performance with diastolic dysfunction in adult spontaneously hypertensive rats. In: Hypertension. 2003 ; Vol. 41, No. 2. pp. 249-254.
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