TY - JOUR
T1 - Increased systemic microbial translocation is associated with depression during early pregnancy
AU - Zhou, Zejun
AU - Guille, Constance
AU - Ogunrinde, Elizabeth
AU - Liu, Renyu
AU - Luo, Zhenwu
AU - Powell, Anna
AU - Jiang, Wei
N1 - Funding Information:
This work was supported by National Institutes of Health Grants AI091526 and AI128864 (to WJ), the Medical Research Service at the Ralph H. Johnson VA Medical Center Merit Grant VA CSRD MERIT CX001211 (to WJ), Building Interdisciplinary Research Careers in Women's Health Career Development Award K12HD055885 (to CG), South Carolina Clinical and Translational Research Institute Pilot Grant Program Grant UL1 TR000062 (to CG), and Career Development Award from the National Institute on Drug Abuse Grant 1K23DA039318-01 (to CG).
Publisher Copyright:
© 2017
PY - 2018/2
Y1 - 2018/2
N2 - Plasma level of microbial translocation is a marker of mucosal permeability. Increased mucosal permeability ignites elevated microbial translocation and as a consequence of systemic inflammation. Pregnant women with depression have higher levels of inflammatory markers relative to pregnant women without depression, however, no studies have reported whether systemic microbial translocation will change in depressed women during pregnancy. In this study, we examined the plasma LPS level of depressed women during pregnancy. The results showed that the plasma LPS level was significantly increased in depressed mothers during their 8–12 weeks gestation compared to healthy controls. Compared to 8–12 weeks gestation, the plasma LPS levels were significantly decreased at 24–28 weeks gestation and 6–8 weeks postpartum in both depressed subjects and healthy controls. Furthermore, the plasma levels of pro-inflammatory cytokines (TNF-α and MCP/CCL2) associated with microbial translocation were significantly increased in depressed subjects during 8–12 weeks gestation compared to healthy controls. These results indicate that the level of microbial translocation is increased in depressed women during early pregnancy.
AB - Plasma level of microbial translocation is a marker of mucosal permeability. Increased mucosal permeability ignites elevated microbial translocation and as a consequence of systemic inflammation. Pregnant women with depression have higher levels of inflammatory markers relative to pregnant women without depression, however, no studies have reported whether systemic microbial translocation will change in depressed women during pregnancy. In this study, we examined the plasma LPS level of depressed women during pregnancy. The results showed that the plasma LPS level was significantly increased in depressed mothers during their 8–12 weeks gestation compared to healthy controls. Compared to 8–12 weeks gestation, the plasma LPS levels were significantly decreased at 24–28 weeks gestation and 6–8 weeks postpartum in both depressed subjects and healthy controls. Furthermore, the plasma levels of pro-inflammatory cytokines (TNF-α and MCP/CCL2) associated with microbial translocation were significantly increased in depressed subjects during 8–12 weeks gestation compared to healthy controls. These results indicate that the level of microbial translocation is increased in depressed women during early pregnancy.
KW - Inflammation
KW - Microbial translocation
KW - Mucosal permeability
KW - Peripartum depression
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U2 - 10.1016/j.jpsychires.2017.11.009
DO - 10.1016/j.jpsychires.2017.11.009
M3 - Article
C2 - 29179013
AN - SCOPUS:85034825279
SN - 0022-3956
VL - 97
SP - 54
EP - 57
JO - Journal of Psychiatric Research
JF - Journal of Psychiatric Research
ER -