Increased susceptibility to mycoplasma infection in patients with hypogammaglobulinemia

Chaim M. Roifman, C. Pandu Rao, Howard M. Lederman, Sasson Lavi, Patricia Quinn, Erwin W. Gelfand

Research output: Contribution to journalArticlepeer-review


The incidence and morbidity of Mycoplasma infections were examined in a group of 23 patients with hypogammaglobulinemia. Among this group of patients, 18 had one or more episodes of acute respiratory illness during which Ureaplasma urealyticum, Mycoplasma orale, or Mycoplasma pneumoniae were isolated from sputum. Resolution only followed institution of specific antibiotic therapy and elimination of the Mycoplasma. In addition to respiratory illness, U. urealyticum was isolated from the urine of two patients with urinary tract infection and from an area of cellulitis in another patient. M. pneumoniae was isolated from the joint of a patient with arthritis. In six patients with chronic lung disease, Mycoplasma was frequently isolated and clinical improvement, albeit transient, coincided with negative Mycoplasma culture results. These findings emphasize the unique susceptibility to Mycoplasma infection in patients with hypogammaglobulinemia.

Original languageEnglish (US)
Pages (from-to)590-594
Number of pages5
JournalThe American journal of medicine
Issue number4
StatePublished - Apr 1986
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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