Increased stereotypy in conditional Cxcr4 knockout mice

Tyler Cash-Padgett, Akira Sawa, Hanna Jaaro-Peled

Research output: Contribution to journalArticle

Abstract

Chemokines play important roles in the central nervous system, including mediating neuroinflammation and guiding the intracortical migration of interneurons during development. Alteration in parvalbumin-positive interneurons is a key neuropathological hallmark of multiple mental conditions. We recently reported a significant reduction in the expression of CXCL12 in olfactory neurons from sporadic cases with schizophrenia compared with matched controls, suggesting a role for CXCR4/CXCL12 signaling in mental conditions. Thus, we depleted the chemokine receptor Cxcr4 from mice using the parvalbumin-2A-Cre line. The conditional knockout mice exhibited a unique behavioral phenotype involving increased stereotypy. Stereotypy is observed in many psychiatric conditions, including schizophrenia, autism, and dementia. Thus, the Cxcr4 conditional knockout mice may serve as a model for this symptomatic feature.

Original languageEnglish (US)
Pages (from-to)75-79
Number of pages5
JournalNeuroscience Research
Volume105
DOIs
StatePublished - Apr 1 2016

Keywords

  • Behavior
  • CXCR4
  • Chemokines
  • Mouse models
  • Parvalbumin interneurons
  • Stereotypy

ASJC Scopus subject areas

  • Neuroscience(all)

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