Increased soluble platelet/endothelial cellular adhesion molecule-1 and osteonectin levels in patients with severe congestive heart failure. Independence of disease etiology, and antecedent aspirin therapy

Victor L. Serebruany, Selva R. Murugesan, Anitha Pothula, Dan Atar, David R. Lowry, Christopher M. O'Connor, Paul A. Gurbel

Research output: Contribution to journalArticle

Abstract

Background: Platelet-endothelial interactions modulated by adhesion molecules, may play an important role in the pathogenesis of congestive heart failure (CHF). Soluble levels of these molecules and platelet-derived substances are reportedly elevated in patients with CHF. However, no data are available on the plasma levels of Platelet/Endothelial Cell Adhesion Molecule-1 (PECAM-1), and platelet-derived osteonectin in this growing population. Methods and Results: Soluble levels by ELISA were prospectively determined in patients with severe CHF (n = 37) and correlated to etiology and antecedent aspirin use, and compared with 14 healthy control subjects. Left ventricular dysfunction was attributed to idiopathic dilated cardiomyopathy in 18 and coronary artery disease in 19 patients. Twenty-one patients were aspirin-free and 16 patients were using aspirin (81-500 mg daily). Elevated soluble PECAM-1 (51.31 ± 2.44 ng/ml, P= 0.0001), and osteonectin (826.27 ± 22.37 ng/ml, P = 0.0001) were observed in patients with CHF, as compared to healthy controls (32.56 ± 1.21 ng/ml, and 478.02 ± 31.32 ng/ml, respectively). Neither etiology of CHF, nor antecedent aspirin therapy significantly affects the levels of PECAM-1 or osteonectin. Conclusions: Despite long-term aspirin therapy and independently of the etiology of the disease, soluble PECAM-1 and osteonectin were elevated in the majority of patients with severe CHF, suggesting platelet-endothelial activation. The present data provide additional evidence that more potent anti-platelet and endothelial preservation regimens deserve further study in the heart failure population. (C) 1999 European Society of Cardiology.

Original languageEnglish (US)
Pages (from-to)243-249
Number of pages7
JournalEuropean Journal of Heart Failure
Volume1
Issue number3
DOIs
StatePublished - Aug 31 1999

Fingerprint

Osteonectin
Aspirin
CD31 Antigens
Blood Platelets
Heart Failure
Therapeutics
Platelet Activation
Dilated Cardiomyopathy
Left Ventricular Dysfunction
Population
Coronary Artery Disease
Healthy Volunteers
Enzyme-Linked Immunosorbent Assay

Keywords

  • Aspirin
  • Congestive heart failure
  • Osteonectin
  • PECAM-1

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Increased soluble platelet/endothelial cellular adhesion molecule-1 and osteonectin levels in patients with severe congestive heart failure. Independence of disease etiology, and antecedent aspirin therapy. / Serebruany, Victor L.; Murugesan, Selva R.; Pothula, Anitha; Atar, Dan; Lowry, David R.; O'Connor, Christopher M.; Gurbel, Paul A.

In: European Journal of Heart Failure, Vol. 1, No. 3, 31.08.1999, p. 243-249.

Research output: Contribution to journalArticle

Serebruany, Victor L. ; Murugesan, Selva R. ; Pothula, Anitha ; Atar, Dan ; Lowry, David R. ; O'Connor, Christopher M. ; Gurbel, Paul A. / Increased soluble platelet/endothelial cellular adhesion molecule-1 and osteonectin levels in patients with severe congestive heart failure. Independence of disease etiology, and antecedent aspirin therapy. In: European Journal of Heart Failure. 1999 ; Vol. 1, No. 3. pp. 243-249.
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abstract = "Background: Platelet-endothelial interactions modulated by adhesion molecules, may play an important role in the pathogenesis of congestive heart failure (CHF). Soluble levels of these molecules and platelet-derived substances are reportedly elevated in patients with CHF. However, no data are available on the plasma levels of Platelet/Endothelial Cell Adhesion Molecule-1 (PECAM-1), and platelet-derived osteonectin in this growing population. Methods and Results: Soluble levels by ELISA were prospectively determined in patients with severe CHF (n = 37) and correlated to etiology and antecedent aspirin use, and compared with 14 healthy control subjects. Left ventricular dysfunction was attributed to idiopathic dilated cardiomyopathy in 18 and coronary artery disease in 19 patients. Twenty-one patients were aspirin-free and 16 patients were using aspirin (81-500 mg daily). Elevated soluble PECAM-1 (51.31 ± 2.44 ng/ml, P= 0.0001), and osteonectin (826.27 ± 22.37 ng/ml, P = 0.0001) were observed in patients with CHF, as compared to healthy controls (32.56 ± 1.21 ng/ml, and 478.02 ± 31.32 ng/ml, respectively). Neither etiology of CHF, nor antecedent aspirin therapy significantly affects the levels of PECAM-1 or osteonectin. Conclusions: Despite long-term aspirin therapy and independently of the etiology of the disease, soluble PECAM-1 and osteonectin were elevated in the majority of patients with severe CHF, suggesting platelet-endothelial activation. The present data provide additional evidence that more potent anti-platelet and endothelial preservation regimens deserve further study in the heart failure population. (C) 1999 European Society of Cardiology.",
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T1 - Increased soluble platelet/endothelial cellular adhesion molecule-1 and osteonectin levels in patients with severe congestive heart failure. Independence of disease etiology, and antecedent aspirin therapy

AU - Serebruany, Victor L.

AU - Murugesan, Selva R.

AU - Pothula, Anitha

AU - Atar, Dan

AU - Lowry, David R.

AU - O'Connor, Christopher M.

AU - Gurbel, Paul A.

PY - 1999/8/31

Y1 - 1999/8/31

N2 - Background: Platelet-endothelial interactions modulated by adhesion molecules, may play an important role in the pathogenesis of congestive heart failure (CHF). Soluble levels of these molecules and platelet-derived substances are reportedly elevated in patients with CHF. However, no data are available on the plasma levels of Platelet/Endothelial Cell Adhesion Molecule-1 (PECAM-1), and platelet-derived osteonectin in this growing population. Methods and Results: Soluble levels by ELISA were prospectively determined in patients with severe CHF (n = 37) and correlated to etiology and antecedent aspirin use, and compared with 14 healthy control subjects. Left ventricular dysfunction was attributed to idiopathic dilated cardiomyopathy in 18 and coronary artery disease in 19 patients. Twenty-one patients were aspirin-free and 16 patients were using aspirin (81-500 mg daily). Elevated soluble PECAM-1 (51.31 ± 2.44 ng/ml, P= 0.0001), and osteonectin (826.27 ± 22.37 ng/ml, P = 0.0001) were observed in patients with CHF, as compared to healthy controls (32.56 ± 1.21 ng/ml, and 478.02 ± 31.32 ng/ml, respectively). Neither etiology of CHF, nor antecedent aspirin therapy significantly affects the levels of PECAM-1 or osteonectin. Conclusions: Despite long-term aspirin therapy and independently of the etiology of the disease, soluble PECAM-1 and osteonectin were elevated in the majority of patients with severe CHF, suggesting platelet-endothelial activation. The present data provide additional evidence that more potent anti-platelet and endothelial preservation regimens deserve further study in the heart failure population. (C) 1999 European Society of Cardiology.

AB - Background: Platelet-endothelial interactions modulated by adhesion molecules, may play an important role in the pathogenesis of congestive heart failure (CHF). Soluble levels of these molecules and platelet-derived substances are reportedly elevated in patients with CHF. However, no data are available on the plasma levels of Platelet/Endothelial Cell Adhesion Molecule-1 (PECAM-1), and platelet-derived osteonectin in this growing population. Methods and Results: Soluble levels by ELISA were prospectively determined in patients with severe CHF (n = 37) and correlated to etiology and antecedent aspirin use, and compared with 14 healthy control subjects. Left ventricular dysfunction was attributed to idiopathic dilated cardiomyopathy in 18 and coronary artery disease in 19 patients. Twenty-one patients were aspirin-free and 16 patients were using aspirin (81-500 mg daily). Elevated soluble PECAM-1 (51.31 ± 2.44 ng/ml, P= 0.0001), and osteonectin (826.27 ± 22.37 ng/ml, P = 0.0001) were observed in patients with CHF, as compared to healthy controls (32.56 ± 1.21 ng/ml, and 478.02 ± 31.32 ng/ml, respectively). Neither etiology of CHF, nor antecedent aspirin therapy significantly affects the levels of PECAM-1 or osteonectin. Conclusions: Despite long-term aspirin therapy and independently of the etiology of the disease, soluble PECAM-1 and osteonectin were elevated in the majority of patients with severe CHF, suggesting platelet-endothelial activation. The present data provide additional evidence that more potent anti-platelet and endothelial preservation regimens deserve further study in the heart failure population. (C) 1999 European Society of Cardiology.

KW - Aspirin

KW - Congestive heart failure

KW - Osteonectin

KW - PECAM-1

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