Abstract
Objective Age-associated skeletal muscle weakness is a major contributing factor to an increased late life mortality and morbidity, but its neurobiology is poorly understood. Previously, we provided histological evidence of dying-back axonal degeneration of motor neurons and denervation of neuromuscular junctions in age-associated muscle weakness. Given this, we aimed to evaluate the relation between impaired neuromuscular transmission and various aspects of age-associated muscle weakness. Design We compared two electrophysiological measures, single-fiber jitter and compound motor action potential in mice of different age groups, and correlated them with various physical performance measures, such as grip strength, standing and walking time, and treadmill performance. Results Consistent with our previous histological data, single-fiber jitter, a measure of neuromuscular junction transmission, was significantly increased in older animals, whereas compound motor action potential shows no difference between young and old age groups. Neither jitter nor compound motor action potential correlated with any of physical performance measures, except for jitter and standing activity. Conclusions Impaired neuromuscular transmission-represented as increase in single-fiber electromyography jitter level-reflects decline in motor function with aging.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 551-556 |
| Number of pages | 6 |
| Journal | American Journal of Physical Medicine and Rehabilitation |
| Volume | 97 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 1 2018 |
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Keywords
- Aging
- Axon
- Dying-Back
- Electrophysiology
- Frailty
- Neuromuscular Junction
- Sarcopenia
- Single-Fiber Electromyography
ASJC Scopus subject areas
- Physical Therapy, Sports Therapy and Rehabilitation
- Rehabilitation
Cite this
Increased Single-Fiber Jitter Level Is Associated with Reduction in Motor Function with Aging. / Chung, Tae; Tian, Yanli; Walston, Jeremy D; Hoke, Ahmet.
In: American Journal of Physical Medicine and Rehabilitation, Vol. 97, No. 8, 01.08.2018, p. 551-556.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Increased Single-Fiber Jitter Level Is Associated with Reduction in Motor Function with Aging
AU - Chung, Tae
AU - Tian, Yanli
AU - Walston, Jeremy D
AU - Hoke, Ahmet
PY - 2018/8/1
Y1 - 2018/8/1
N2 - Objective Age-associated skeletal muscle weakness is a major contributing factor to an increased late life mortality and morbidity, but its neurobiology is poorly understood. Previously, we provided histological evidence of dying-back axonal degeneration of motor neurons and denervation of neuromuscular junctions in age-associated muscle weakness. Given this, we aimed to evaluate the relation between impaired neuromuscular transmission and various aspects of age-associated muscle weakness. Design We compared two electrophysiological measures, single-fiber jitter and compound motor action potential in mice of different age groups, and correlated them with various physical performance measures, such as grip strength, standing and walking time, and treadmill performance. Results Consistent with our previous histological data, single-fiber jitter, a measure of neuromuscular junction transmission, was significantly increased in older animals, whereas compound motor action potential shows no difference between young and old age groups. Neither jitter nor compound motor action potential correlated with any of physical performance measures, except for jitter and standing activity. Conclusions Impaired neuromuscular transmission-represented as increase in single-fiber electromyography jitter level-reflects decline in motor function with aging.
AB - Objective Age-associated skeletal muscle weakness is a major contributing factor to an increased late life mortality and morbidity, but its neurobiology is poorly understood. Previously, we provided histological evidence of dying-back axonal degeneration of motor neurons and denervation of neuromuscular junctions in age-associated muscle weakness. Given this, we aimed to evaluate the relation between impaired neuromuscular transmission and various aspects of age-associated muscle weakness. Design We compared two electrophysiological measures, single-fiber jitter and compound motor action potential in mice of different age groups, and correlated them with various physical performance measures, such as grip strength, standing and walking time, and treadmill performance. Results Consistent with our previous histological data, single-fiber jitter, a measure of neuromuscular junction transmission, was significantly increased in older animals, whereas compound motor action potential shows no difference between young and old age groups. Neither jitter nor compound motor action potential correlated with any of physical performance measures, except for jitter and standing activity. Conclusions Impaired neuromuscular transmission-represented as increase in single-fiber electromyography jitter level-reflects decline in motor function with aging.
KW - Aging
KW - Axon
KW - Dying-Back
KW - Electrophysiology
KW - Frailty
KW - Neuromuscular Junction
KW - Sarcopenia
KW - Single-Fiber Electromyography
UR - http://www.scopus.com/inward/record.url?scp=85050100169&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85050100169&partnerID=8YFLogxK
U2 - 10.1097/PHM.0000000000000915
DO - 10.1097/PHM.0000000000000915
M3 - Article
C2 - 29498943
AN - SCOPUS:85050100169
VL - 97
SP - 551
EP - 556
JO - American Journal of Physical Medicine and Rehabilitation
JF - American Journal of Physical Medicine and Rehabilitation
SN - 0894-9115
IS - 8
ER -