Increased serum soluble interleukin-2 receptors in caucasian and Korean schizophrenic patients

Mark Hyman Rapaport, Cathy G. McAllister, Sik Kim Yong Sik Kim, Hee Han Jin Hee Han, David Pickar, David L. Nelson, Darrell G. Kirch, Steven M. Paul

Research output: Contribution to journalArticle

Abstract

Recent studies have identified immunologic abnormalities in some schizophrenic subjects. This experiment replicates previous findings that serum soluble interleukin-2 receptors (SIL-2Rs) are elevated in schizophrenic patients, and is the first study to describe this phenomenon in non-Caucasian patients. Despite differences between Korean and Caucasian schizophrenic patients in absolute serum SIL-2R levels, both groups were significantly elevated when compared with their respective ethnic control groups (477 ± 171 U/ml versus 354 ± 172 U/ml and 763±347 U/ml versus 567±231 U/ml, respectively). Neither age, gender, medication status, nor duration of illness correlated with SIL-2R levels. These findings are further evidence that immune activation is present, regardless of ethnic origin, in some schizophrenic patients.

Original languageEnglish (US)
Pages (from-to)767-771
Number of pages5
JournalBiological Psychiatry
Volume35
Issue number10
DOIs
StatePublished - May 15 1994
Externally publishedYes

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Keywords

  • biological psychiatry
  • ethnicity
  • immunology
  • psychotropic medication
  • Schizophrenia
  • SIL-2Rs

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Rapaport, M. H., McAllister, C. G., Yong Sik Kim, S. K., Jin Hee Han, H. H., Pickar, D., Nelson, D. L., Kirch, D. G., & Paul, S. M. (1994). Increased serum soluble interleukin-2 receptors in caucasian and Korean schizophrenic patients. Biological Psychiatry, 35(10), 767-771. https://doi.org/10.1016/0006-3223(94)91137-1