Increased sensitivity to supra-threshold painful stimuli in patients with multiple functional somatic symptoms (MFS)

Ruta Kuzminskyte, Ron Kupers, Poul Videbech, Albert Gjedde, Per Fink

Research output: Contribution to journalArticle

Abstract

Many patients in a variety of medical settings suffer from persistently painful bodily symptoms that are not explained by known pathophysiological mechanisms. In the most severe cases, these patients complain of multiple functional somatic symptoms (MFS). We tested the hypothesis of reduced pain threshold and pain tolerance levels in patients with MFS. Twenty-two patients with MFS and 27 age- and sex-matched healthy control subjects volunteered for this study. The subjects received innocuous and noxious thermal stimuli to the volar forearm by means of a Peltier contact heat probe. We assessed pain threshold and pain tolerance with an ascending staircase method. Anxiety levels and hemodynamic (blood pressure, pulse rate) and endocrine (cortisol and prolactin release) responses were measured before and after pain testing. We found no group differences for any of the physiological or self-rated subjective emotional responses to the pain stressor. Contrary to the hypothesis, the pain threshold was not lower in MFS; the data even showed a trend in the opposite direction. Pain tolerance scores were identical in the two groups but they correlated negatively with the number of functional somatic symptoms in MFS patients. Importantly, patients had a smaller temperature range between their pain threshold and pain tolerance scores, suggesting that they differentiate poorly within the noxious range. Minor increases in stimulus intensity of supra-threshold painful stimuli may lead to disproportionate increases in pain intensity in MFS patients, suggesting a defunct endogenous pain modulatory system.

Original languageEnglish (US)
Pages (from-to)135-140
Number of pages6
JournalBrain Research Bulletin
Volume82
Issue number1-2
DOIs
StatePublished - Apr 2010
Externally publishedYes

Fingerprint

Pain
Pain Threshold
Hot Temperature
Medically Unexplained Symptoms
Forearm
Prolactin
Hydrocortisone
Healthy Volunteers
Anxiety
Heart Rate
Hemodynamics
Blood Pressure
Temperature

Keywords

  • Disability
  • Multiple functional somatic symptoms
  • Pain modulation
  • Pain responsiveness
  • Quantitative sensory testing

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Increased sensitivity to supra-threshold painful stimuli in patients with multiple functional somatic symptoms (MFS). / Kuzminskyte, Ruta; Kupers, Ron; Videbech, Poul; Gjedde, Albert; Fink, Per.

In: Brain Research Bulletin, Vol. 82, No. 1-2, 04.2010, p. 135-140.

Research output: Contribution to journalArticle

Kuzminskyte, Ruta ; Kupers, Ron ; Videbech, Poul ; Gjedde, Albert ; Fink, Per. / Increased sensitivity to supra-threshold painful stimuli in patients with multiple functional somatic symptoms (MFS). In: Brain Research Bulletin. 2010 ; Vol. 82, No. 1-2. pp. 135-140.
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