Increased sensitivity to nifedipine of smooth muscle from hypertensive rats

E. Amado Cattaneo; G. J. Rinaldi; O. A. Gende; R. A. Venosa; H. E. Cingolani

doi:10.1097/00005344-198609000-00005

Increased sensitivity to nifedipine of smooth muscle from hypertensive rats

E. Amado Cattaneo, G. J. Rinaldi, O. A. Gende, R. A. Venosa, H. E. Cingolani

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The sensitivity of smooth muscle from aortas of spontaneously hypertensive rats (SHR), renal hypertensive rats: Two kidney-one clip and one kidney-one clip (2K 1C, 1K 1C) and DOCA salt hypertensive rats to the relaxant effect of nifedipine (NIF) was studied. A parallel leftward shift of the concentration-relaxation curve was detected in the K-precontracted aortic smooth muscle from hypertensive rats. This increased sensitivity seems to be related to the degree of hypertension and independent of the experimental method used to produce the high blood pressure level. No change in sensitivity was detected either in SHR or in renal hypertensive rats when mitroglycerin was used as a vasodilator.

Original language	English (US)
Pages (from-to)	915-920
Number of pages	6
Journal	Journal of cardiovascular pharmacology
Volume	8
Issue number	5
DOIs	https://doi.org/10.1097/00005344-198609000-00005
State	Published - Sep 1986
Externally published	Yes

Keywords

Arterial hypertension
Dihydropiridines
Nifedipine sensitivity
Smooth muscle in hypertension

ASJC Scopus subject areas

Pharmacology
Cardiology and Cardiovascular Medicine

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10.1097/00005344-198609000-00005

Cite this

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abstract = "The sensitivity of smooth muscle from aortas of spontaneously hypertensive rats (SHR), renal hypertensive rats: Two kidney-one clip and one kidney-one clip (2K 1C, 1K 1C) and DOCA salt hypertensive rats to the relaxant effect of nifedipine (NIF) was studied. A parallel leftward shift of the concentration-relaxation curve was detected in the K-precontracted aortic smooth muscle from hypertensive rats. This increased sensitivity seems to be related to the degree of hypertension and independent of the experimental method used to produce the high blood pressure level. No change in sensitivity was detected either in SHR or in renal hypertensive rats when mitroglycerin was used as a vasodilator.",

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AU - Amado Cattaneo, E.

AU - Rinaldi, G. J.

AU - Gende, O. A.

AU - Venosa, R. A.

AU - Cingolani, H. E.

PY - 1986/9

Y1 - 1986/9

N2 - The sensitivity of smooth muscle from aortas of spontaneously hypertensive rats (SHR), renal hypertensive rats: Two kidney-one clip and one kidney-one clip (2K 1C, 1K 1C) and DOCA salt hypertensive rats to the relaxant effect of nifedipine (NIF) was studied. A parallel leftward shift of the concentration-relaxation curve was detected in the K-precontracted aortic smooth muscle from hypertensive rats. This increased sensitivity seems to be related to the degree of hypertension and independent of the experimental method used to produce the high blood pressure level. No change in sensitivity was detected either in SHR or in renal hypertensive rats when mitroglycerin was used as a vasodilator.

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KW - Arterial hypertension

KW - Dihydropiridines

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KW - Smooth muscle in hypertension

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Increased sensitivity to nifedipine of smooth muscle from hypertensive rats

Abstract

Keywords

ASJC Scopus subject areas

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