Increased sensitivity to nifedipine of smooth muscle from hypertensive rats

E. Amado Cattaneo, G. J. Rinaldi, O. A. Gende, R. A. Venosa, H. E. Cingolani

Research output: Contribution to journalArticle

Abstract

The sensitivity of smooth muscle from aortas of spontaneously hypertensive rats (SHR), renal hypertensive rats: Two kidney-one clip and one kidney-one clip (2K 1C, 1K 1C) and DOCA salt hypertensive rats to the relaxant effect of nifedipine (NIF) was studied. A parallel leftward shift of the concentration-relaxation curve was detected in the K-precontracted aortic smooth muscle from hypertensive rats. This increased sensitivity seems to be related to the degree of hypertension and independent of the experimental method used to produce the high blood pressure level. No change in sensitivity was detected either in SHR or in renal hypertensive rats when mitroglycerin was used as a vasodilator.

Original languageEnglish (US)
Pages (from-to)915-920
Number of pages6
JournalJournal of cardiovascular pharmacology
Volume8
Issue number5
DOIs
StatePublished - Sep 1986

Keywords

  • Arterial hypertension
  • Dihydropiridines
  • Nifedipine sensitivity
  • Smooth muscle in hypertension

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

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    Amado Cattaneo, E., Rinaldi, G. J., Gende, O. A., Venosa, R. A., & Cingolani, H. E. (1986). Increased sensitivity to nifedipine of smooth muscle from hypertensive rats. Journal of cardiovascular pharmacology, 8(5), 915-920. https://doi.org/10.1097/00005344-198609000-00005