Increased sensitivity of cerebrohepatorenal syndrome fibroblasts to antimycin A

R. I. Kelley; B. E. Corkey

doi:10.1007/BF02310872

Increased sensitivity of cerebrohepatorenal syndrome fibroblasts to antimycin A

R. I. Kelley, B. E. Corkey

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Abstract

The effect of four mitochondrial electron transport inhibitors on the growth of normal and cerebrohepatorenal syndrome (CHRS) fibroblasts was studied. Compared to normal fibroblasts, CHRS cells demonstrated a fivefold greater sensitivity to antimycin A, an inhibitor of the cytochrome bc₁ complex (complex III), but equal inhibition by amytal, rotenone and 2-heptyl-4-hydroxyquinoline-N-oxide. The results suggest a primary or secondary functional deficiency at mitochondrial complex III in fibroblasts.

Original language	English (US)
Pages (from-to)	158-162
Number of pages	5
Journal	Journal of Inherited Metabolic Disease
Volume	6
Issue number	4
DOIs	https://doi.org/10.1007/BF02310872
State	Published - Dec 1983
Externally published	Yes

ASJC Scopus subject areas

Genetics
Genetics(clinical)

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title = "Increased sensitivity of cerebrohepatorenal syndrome fibroblasts to antimycin A",

abstract = "The effect of four mitochondrial electron transport inhibitors on the growth of normal and cerebrohepatorenal syndrome (CHRS) fibroblasts was studied. Compared to normal fibroblasts, CHRS cells demonstrated a fivefold greater sensitivity to antimycin A, an inhibitor of the cytochrome bc1 complex (complex III), but equal inhibition by amytal, rotenone and 2-heptyl-4-hydroxyquinoline-N-oxide. The results suggest a primary or secondary functional deficiency at mitochondrial complex III in fibroblasts.",

author = "Kelley, {R. I.} and Corkey, {B. E.}",

year = "1983",

month = dec,

doi = "10.1007/BF02310872",

language = "English (US)",

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pages = "158--162",

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T1 - Increased sensitivity of cerebrohepatorenal syndrome fibroblasts to antimycin A

AU - Kelley, R. I.

AU - Corkey, B. E.

PY - 1983/12

Y1 - 1983/12

N2 - The effect of four mitochondrial electron transport inhibitors on the growth of normal and cerebrohepatorenal syndrome (CHRS) fibroblasts was studied. Compared to normal fibroblasts, CHRS cells demonstrated a fivefold greater sensitivity to antimycin A, an inhibitor of the cytochrome bc1 complex (complex III), but equal inhibition by amytal, rotenone and 2-heptyl-4-hydroxyquinoline-N-oxide. The results suggest a primary or secondary functional deficiency at mitochondrial complex III in fibroblasts.

AB - The effect of four mitochondrial electron transport inhibitors on the growth of normal and cerebrohepatorenal syndrome (CHRS) fibroblasts was studied. Compared to normal fibroblasts, CHRS cells demonstrated a fivefold greater sensitivity to antimycin A, an inhibitor of the cytochrome bc1 complex (complex III), but equal inhibition by amytal, rotenone and 2-heptyl-4-hydroxyquinoline-N-oxide. The results suggest a primary or secondary functional deficiency at mitochondrial complex III in fibroblasts.

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JF - Journal of Inherited Metabolic Disease

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ER -

Increased sensitivity of cerebrohepatorenal syndrome fibroblasts to antimycin A

Abstract

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