Increased risk of breast cancer in women with NF1

Sara Aileen Madanikia, Amanda Bergner, Xiaobu Ye, Jaishri Blakeley

Research output: Contribution to journalArticle

Abstract

Neurofibromatosis type 1 (NF1) is a common autosomal dominant disorder associated with increased risk for neoplasms. Two studies in the United Kingdom have indicated that women with NF1 (particularly women under 50) may also be at increased risk of breast cancer. No such study has been done to date in the United States. Chart review for breast cancer diagnoses was undertaken for 126 women with NF1 followed at Johns Hopkins who were 20 years of age or older. Four of 126 women who met eligibility criteria were diagnosed with breast cancer (3.2% over 15 years). The unadjusted standardized incidence ratio (SIR) for breast cancer in the NF1 population between the ages of 20 and 49 was 2.68 (P=0.076, 95% CI 0.68-7.29) based on incidence rates of breast cancer in the general population taken from the Surveillance Epidemiology and End Results (SEER) database. The unadjusted SIR for women with NF1 ≥50 was 0.81 (P=0.84, 95% CI 0.041-4.01). When adjusted for race, the rate of NF1 in the general population and time of diagnosis, the SIR was 4.41 (P=0.0049, 95% CI 1.12-12.00) for women

Original languageEnglish (US)
Pages (from-to)3056-3060
Number of pages5
JournalAmerican Journal of Medical Genetics, Part A
Volume158 A
Issue number12
DOIs
StatePublished - Dec 2012

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Keywords

  • Breast neoplasms
  • Historical cohort study
  • Neurofibromatosis 1
  • SEER program

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

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