@article{46b28f304b094a16907c307f132db51f,
title = "Increased risk of asthma and atopic dermatitis in perinatally HIV-infected children and adolescents",
abstract = "The incidence of asthma and atopic dermatitis (AD) was evaluated in HIV-infected (n = 451) compared to HIV-exposed (n = 227) but uninfected (HEU) children and adolescents by abstraction from clinical charts. Asthma was more common in HIV-infected compared to HEU children by clinical diagnosis (25% vs. 20%, p = 0.101), by asthma medication use, (31% vs. 22%, p = 0.012), and by clinical diagnosis and/or medication use, (34% vs. 25%, p = 0.012). HIV-infected children had a greater risk of asthma compared to HEU children (HR = 1.37, 95% CI: 1.01 to 1.86). AD was more common in HIV-infected than HEU children (20% vs. 12%, p = 0.009)) and children with AD were more likely to have asthma in both cohorts (41% vs. 29%, p = 0.010). HIV-infected children and adolescents in this study had an increased incidence of asthma and AD, a finding critical for millions of HIV-infected children worldwide.",
keywords = "Asthma, Atopic dermatitis, Inhaled corticosteroids, Pediatric HIV infection, Protease inhibitors",
author = "Siberry, {George K.} and Erin Leister and Jacobson, {Denise L.} and Foster, {Samuel B.} and Seage, {George R.} and Lipshultz, {Steven E.} and Paul, {Mary E.} and Murli Purswani and Colin, {Andrew A.} and Gwendolyn Scott and Shearer, {William T.}",
note = "Funding Information: We thank the children and families for their participation in PHACS, and the individuals and institutions involved in the conduct of PHACS. The study was supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development with co-funding from the National Institute on Drug Abuse , the National Institute of Allergy and Infectious Diseases , the National Institute of Mental Health , the National Institute of Neurological Disorders and Stroke , the National Institute of Deafness and Other Communication Disorders , the National Heart Lung and Blood Institute , and the National Institute on Alcohol Abuse and Alcoholism through cooperative agreements with the Harvard University School of Public Health (HD052102, 3 U01 HD052102-05S1, 3 U01 HD052102-06S3) (Principal Investigator: George Seage; Project Director: Julie Alperen) and the Tulane University School of Medicine (HD052104, 3U01HD052104-06S1) (Principal Investigator: Russell Van Dyke; Co-Principal Investigator: Kenneth Rich; Project Director: Patrick Davis). Additional support was received from the National Institutes of Health grants P30AI36211 and RR0188 . Data management services were provided by Frontier Science and Technology Research Foundation (PI: Suzanne Siminski), and regulatory services and logistical support were provided by Westat, Inc (PI: Julie Davidson). ",
year = "2012",
month = feb,
doi = "10.1016/j.clim.2011.10.005",
language = "English (US)",
volume = "142",
pages = "201--208",
journal = "Clinical Immunology",
issn = "1521-6616",
publisher = "Academic Press Inc.",
number = "2",
}